Results 121 to 130 of about 90,260 (324)

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

Advanced Functional Materials, EarlyView.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila, Anh Ha, Morgan R. Chandler, Nathalia Leal Santos, Taejin Kim, Hannah S. Newton, Marina A. Dobrovolskaia, Kirill A. Afonin   +7 more
wiley   +1 more source

Precise Asteroseismic Ages for the Helmi Streams

The Astrophysical Journal
The Helmi streams are remnants of a dwarf galaxy that was accreted by the Milky Way and whose stars now form a distinct kinematic and chemical substructure in the Galactic halo. Precisely age-dating these typically faint stars of extragalactic origin has
Christopher J. Lindsay, Marc Hon, J. M. Joel Ong, Rafael A. García, Dinil B. Palakkatharappil, Jie Yu, Tanda Li, Tomás Ruiz-Lara, Amina Helmi   +8 more
doaj   +1 more source

Disk Heating, Galactoseismology, and the Formation of Stellar Halos

Galaxies, 2017
Deep photometric surveys of the Milky Way have revealed diffuse structures encircling our Galaxy far beyond the “classical” limits of the stellar disk. This paper reviews results from our own and other observational programs, which together suggest that,
Kathryn V. Johnston, Adrian M. Price-Whelan, Maria Bergemann, Chervin Laporte, Ting S. Li, Allyson A. Sheffield, Steven R. Majewski, Rachael S. Beaton, Branimir Sesar, Sanjib Sharma   +9 more
doaj   +1 more source

Infall Times for Milky Way Satellites From Their Present-Day Kinematics

, 2011
We analyze subhalos in the Via Lactea II (VL2) cosmological simulation to look for correlations among their infall times and z = 0 dynamical properties.
Abramson, Adén, Adén, Angus, Annika H. G. Peter, Aparicio, Barkana, Battaglia, Battaglia, Bekki, Bekki, Bellazzini, Bellazzini, Belokurov, Benson, Benson, Berrier, Besla, Binney, Blanton, Bonanos, Book, Bosler, Bothun, Bovill, Bovill, Boylan-Kolchin, Boylan-Kolchin, Bullock, Bullock, Busha, Butcher, Caputo, Carrera, Cohen, Coleman, Coleman, D'Onghia, D'Onghia, Dall'Ora, de Boer, de Jong, de Jong, De Marchi, Dehnen, Diemand, Diemand, Diemand, Dijkstra, Dolphin, Dressler, Fang, Gallart, Gavazzi, Goto, Governato, Grcevich, Grcevich, Greco, Grillmair, Gullieuszik, Gunn, Harris, Held, Hester, Hurley-Keller, Hurley-Keller, Irwin, James Bullock, Kallivayalil, Kallivayalil, Kauffmann, Kaufmann, Kaufmann, Kazantzidis, Kirby, Kuehn, Kuhlen, Lai, Lanfranchi, Larson, Law, Lee, Lee, Letarte, Ludlow, Lux, Lépine, Madau, Mahajan, Maller, Martin, Martin, Mateo, Mateo, MateoMateo, Mighell, Mighell, Miguel Rocha, Monelli, Monkiewicz, Moore, Norris, Norris, Okamoto, Okamoto, Okamoto, Orban, Peek, Piatek, Piatek, Piatek, Piatek, Pietrzyński, Pietrzyński, Purcell, Reid, Rizzi, Rose, Ryan-Weber, Sales, Sales, Sand, Sand, Santiago-Figueroa, Saviane, Simon, Smecker-Hane, Smecker-Hane, Spergel, Stetson, Strigari, Thoul, Tollerud, Tolstoy, Tonnesen, Watkins, Wechsler, Weisz, Wilkinson, Willman, Willman, Wyse, Xue, Zhao, Zucker, Łokas   +146 more
core   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Light element abundance inhomogeneities in globular clusters: probing star formation and evolution in the early Milky Way [PDF]

, 1994
Michael M. Briley, R. A. Bell, J. E. Hesser, Graeme H. Smith   +3 more
openalex   +1 more source

Antibody‐Programmable Bimetallic Nanozymes for Transcriptional Blockade Therapy in HER2/ER‐Positive Breast Cancer

Advanced Functional Materials, EarlyView.
Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao, Tong Ye, Mingjiang Liu, Jingchao Gao, Lian Tan, Qian Dong, Qingbo Lv, Qianqian Ye, Yu Wang   +8 more
wiley   +1 more source

Colloidal Opaline Composites as Throughput‐Scalable, Fully Transparent, and Color‐Tunable Radiative Cooling Exterior Films for Outdoor Photovoltaics

Advanced Functional Materials, EarlyView.
Particular thermal metamaterials are widely used as daytime radiative coolers merely by embedding thermally emissive nanoparticles (NPs) in liquid resins to form scalable, yet highly efficient cooling films in a cost‐effective way. However, randomly dispersed NPs, prevalently used thus far, cause strong scattering, limiting NP content and cooling ...
YongDeok Cho, Hyeon Ho Kim, Sewon Ahn, Jaewon Lee, Jieun Lee, Kwangjin Kim, Soyul Kwak, Hoodam Lee, Kyungsik Choi, Kyonghwa Song, Seungwoo Lee   +10 more
wiley   +1 more source

Milky Way’s Metal-poor Stars Display Chemical Transition near the Solar Radius

The Astrophysical Journal Letters
The metal-poor stars of a galaxy offer insights into that galaxy’s early formation processes and accretion history. Here, we investigate whether the metal-poor stars of our Milky Way Galaxy exhibit any characteristic trends in Galactocentric distance ...
Khyati Malhan
doaj   +1 more source

Catalytic TiO2 with Self‐Assembled Monolayer for Highly Sensitive, Selective, and Non‐Invasive Monitoring of Sweat L‐Cysteine

Advanced Functional Materials, EarlyView.
A self‐assembled monolayer of 3‐mercaptopropyltrimethoxysilane (MPTS) molecular receptor and titanium oxide‐modified carbon cloth (MPTS/TiO2/CC) was synthesized for the specific detection of sweat L‐cysteine, which is associated with the precision neutrition, cardiovascular system and neuro system.
Xiangjie Chen, Jia Zhu, Jian Shao, Taisong Pan, Guang Yao, Min Gao, Jian Yang, Rui Zhao, Libin Huang, Tao Li, Huanyu Cheng, Yuan Lin   +11 more
wiley   +1 more source