Results 251 to 260 of about 29,732 (304)
Primordial black holes and their gravitational-wave signatures. [PDF]
Living Rev RelativBagui E, Clesse S, De Luca V, Ezquiaga JM, Franciolini G, García-Bellido J, Joana C, Kumar Jain R, Kuroyanagi S, Musco I, Papanikolaou T, Raccanelli A, Renaux-Petel S, Riotto A, Ruiz Morales E, Scalisi M, Sergijenko O, Ünal C, Vennin V, Wands D, LISA Cosmology Working Group. +20 moreeuropepmc +1 more sourceMercaptophenylboronic Acid‐Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus
Advanced Science, EarlyView.This study developes a universal colorimetric ICA platform that integrates broad‐spectrum recognition by 4‐mercaptophenylboronic acid with dual signal enhancement—both colorimetric and catalytic—mediated by a biomimetic magnetic nanozyme. This platform, for the first time, enables simple, convenient, ultrasensitive, and simultaneous screening of ...Qing Yu, Jiaxuan Li, Shuai Zheng, Yajin Hu, Benshun Tian, Meirou Lu, Bing Gu, Chongwen Wang +7 morewiley +1 more sourceMechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin
Advanced Science, EarlyView.Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang +8 morewiley +1 more sourceThe origin of accreted stellar halo populations in the Milky Way using APOGEE,Gaia, and the EAGLE simulations
, 2018 J. Ted Mackereth, Ricardo P. Schiavon, Joel Pfeffer, Christian R. Hayes, Jo Bovy, Borja Anguiano, Carlos Allende Prieto, Sten Hasselquist, Jon A. Holtzman, Jennifer A. Johnson, Steven R. Majewski, R. W. O’Connell, Matthew Shetrone, P. B. Tissera, José G. Fernández-Trincado +14 moreopenalex +2 more sourcesPRO‐LDM: A Conditional Latent Diffusion Model for Protein Sequence Design and Functional Optimization
Advanced Science, EarlyView.PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing +15 morewiley +1 more sourceEBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes
Advanced Science, EarlyView.EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang +9 morewiley +1 more sourceThe Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds
Advanced Science, EarlyView.ZLY032, a dual free fatty acid receptor 1/peroxisome proliferator‐activated receptor δ agonist, accelerates wound healing in normal/diabetic/methicillin‐resistant Staphylococcus aureus‐infected models by promoting angiogenesis, reducing inflammation, and exhibiting antibacterial activity via argininosuccinate lyase targeting, with demonstrated efficacy Manyu Gong, Zhiyuan Du, Tiantian Gong, Yu Wang, Chenchen Yin, Bosi Sun, Zijia Liu, Lianru Chen, Zibin Liao, Wenxin Wang, Tianjiao Zhao, Yifei Wang, Ying Dong, Kexin Wang, Mengru Ma, Weijun Li, Jiacheng Li, Haodong Li, Congcong Lin, Ying Zhang, Yu Liu, Xin Liu, Tao Ban, Hongxia Bao, Ying Zhang, Yang Zhang, Zheng Li, Lei Jiao +27 morewiley +1 more sourceNearby stellar substructures in the Galactic halo from DESI Milky Way Survey Year 1 Data Release
Bokyoung Kim, S. E. Koposov, Ting S. Li, Sophia Lilleengen, Andrew P. Cooper, Andreia Carrillo, Monica Valluri, A. H. Riley, J. Han, J. Aguilar, S. P. Ahlen, Leandro Beraldo e Silva, Davide Bianchi, D. Brooks, Amanda Byström, T. Claybaugh, Shaun Cole, Kyle Dawson, Axel de la Macorra, Jaime E. Forero-Romero, Oleg Y. Gnedin, Satya Gontcho A Gontcho, Gaston Gutierrez, J. Guy, Klaus Honscheid, Robert Kehoe, Namitha Kizhuprakkat, Martin Landriau, L. Le Guillou, M. E. Levi, Gustavo Medina Toledo, Aaron Meisner, Ramon Miquel, John Moustakas, Claire Poppett, F. Prada, Graziano Rossi, E. Sánchez, M. Schubnell, R. M. Sharples, David Sprayberry, J. I. Gónzalez Hernández, Benjamin Alan Weaver, Hu Zou +43 moreopenalex +1 more source