Results 91 to 100 of about 8,155 (173)

Thermoterapy effective and safer than miltefosine in the treatment of cutaneous leishmaniasis in Colombia

Revista do Instituto de Medicina Tropical de São Paulo, 2013
In Colombia, pentavalent antimonials and miltefosine are the drugs of choice for the treatment of cutaneous leishmaniasis; however, their toxicity, treatment duration, (treatment adherence problems), cost, and decreased parasite sensitivity make the ...
Liliana López, Claudia Cruz, Gonzalo Godoy, Sara M. Robledo, Iván D. Vélez   +4 more
doaj   +1 more source

From lipid biophysics to first-in human test: topical liposomal treatment for cutaneous leishmaniasis

Precision Nanomedicine
Cutaneous leishmaniasis (CL) remains a major neglected disease with limited therapeutic op-tions and expanding geographic distribution. To develop a safe, accessible local treatment, we formulated topical Miltefosine gels incorporating different types of
Dolores Catalina Carrer
doaj   +1 more source

Miltefosine release profiles.

, 2015
Miltefosine release from selected lipid nanocapsule formulations in PBS pH 7.4 at 37°C over a 24 h-study period. Data represent mean ± SD (n = 3). The inset is an enlargement of the release profiles for the first 8h of the release study.
Labiba K. El-Khordagui (827790), Mervat Z. El-Azzouni (827789), Maha M. Eissa (827785), Eglal I. Amer (827788), Riham M. El-Moslemany (827786), Alyaa A. Ramadan (827787)   +5 more
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Miltefosine: een nieuw geneesmiddel voor leishmaniasis

, 2006
There is a need for a safe and effective oral treatment for cutaneous and visceral leishmaniasis. Miltefosine is the first oral drug that is efficacious against different forms ofleishmaniasis, however it is not equally effective against all Leishmania ...
Dorlo, T. P. C., Eggelte, T. A., Beijnen, J. H., de Vries, P. J.   +3 more
core  

Physicochemical properties of miltefosine-loaded chitosan nanoparticles.

Physicochemical properties of miltefosine-loaded chitosan nanoparticles.
Alireza Latifi (14593561), Elham Kazemirad (5814692), Fariba Esmaeili (532865), Mostafa Rezaeian (18251282), Amir Amani (1396096), Mehdi Mohebali (62368), Mohammad Soleimani (6642407), Setayesh Yasami-Khiabani (18251279)   +7 more
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A policy for leishmaniasis with respect to the prevention and control of drug resistance. [PDF]

, 2001
At the moment no country has a policy designed to control or prevent drug resistance in leishmaniasis. The risk of resistance is high in areas of anthroponotic visceral leishmaniasis, for example North Bihar, India, where the rate in some areas is 60 ...
Bryceson, A
core   +1 more source

Clinical, histopathological and parasitological follow-up of dogs naturally infected by Leishmania infantum before and after miltefosine treatment and associated therapies.

PLoS ONE
In Brazil, Visceral Leishmaniases is caused by Leishmania infantum, and domestic dogs are the main reservoirs in its urban transmission cycle. As an alternative to euthanizing dogs, miltefosine has been used to treat canine visceral leishmaniasis since ...
Amábilli de Souza Rosar, Carolina Leite Martins, Álvaro Menin, Carolina Reck, Edmundo Carlos Grisard, Glauber Wagner, Mário Steindel, Patricia Hermes Stoco, Patricia Flavia Quaresma   +8 more
doaj   +1 more source

Leishmania miltefosine sensitivity.^a

, 2013
aCultured mid-log-phase promastigotes were seeded at 5×105 cells mL−1 with different miltefosine concentrations (5–200 µM), and the cell density was determined after 48 h.
Ricardo Andrade Zampieri (148278), Marcos Gonzaga dos Santos (148282), Thomas Günther Pomorski (148289), Sandra Marcia Muxel (213095), Lucile Maria Floeter-Winter (278185)   +4 more
core   +1 more source

Miltefosine (Impavido): the first oral treatment against leishmaniasis.

, 2003
Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advantage of oral administration over the currently ...
Engel, Kirsten-Rita, Eibl, HJ, Sindermann, H, Eibl, H., Engel, K., Engel, J., Unger, C., Croft, S. L., Unger, C, Bommer, W., Croft, SL, Engel, J, Engel, KR, Engel, K. R., Croft, S., Eibl, Hans-Joerg, Bommer, W, Sindermann, H.   +17 more
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Miltefosine Administration in Cats with Refractory Sporotrichosis [PDF]

, 2018
Background: Sporotrichosis is a zoonosis caused by fungi of the Sporothrix schenckii complex. Cats have important zoonotic potential due to the high parasite load found in the cutaneous lesions.
Baptista, Vivian dos Santos, Silva, Kássia Valéria Gomes Coelho da, Cunha, Simone Carvalho dos Santos, Silva, Francina dos Santos, Coêlho, Thais Fernanda Queiroz, Baptista, Andrea Regina de Souza, Ferreira, Ana Maria Reis   +6 more
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