Results 81 to 90 of about 8,155 (173)

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

Lipids in Health and Disease, 2010
The alkylphospholipid analog miltefosine (hexadecylphosphocholine) is a membrane-directed antitumoral and antileishmanial drug belonging to the alkylphosphocholines, a group of synthetic antiproliferative agents that are promising candidates in ...
Segovia Josefa L, Marco Carmen, Ríos-Marco Pablo, Jiménez-López José M, Carrasco María P   +4 more
doaj   +1 more source

Characterization and identification of suspected counterfeit miltefosine capsules

, 2012
Recently, it was revealed that generic miltefosine capsules for the treatment of visceral leishmaniasis, a fatal parasitic disease, were possibly counterfeit products.
de Vries, Peter J., Dorlo, Thomas P. C., Dorlo, Thomas P C, Beijnen, Jos H., Eggelte, Teunis A, Eggelte, Teunis A., de Vries, Peter J, Beijnen, Jos H   +7 more
core   +1 more source

Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure [PDF]

, 2014
BACKGROUND: Recent reports indicated high miltefosine treatment failure rates for visceral leishmaniasis (VL) on the Indian subcontinent. To further explore the pharmacological factors associated with these treatment failures, a population ...
Uranw, Surendra, Huitema, Alwin D R, Beijnen, Jos H., Singh, Rupa, de Vries, Peter J, Huitema, Alwin D. R., Dujardin, Jean-Claude, de Vries, Peter J., Pharmacoepidemiology and Clinical Pharmacology, Dorlo, Thomas P. C., Dorlo, Thomas P C, Rijal, Suman, Sub Clinical Pharmacology, Ostyn, Bart, Bhattarai, Narayan, Boelaert, Marleen, Beijnen, Jos H   +16 more
core   +1 more source

Advanced case of PKDL due to delayed treatment: A rare case report.

PLoS Neglected Tropical Diseases, 2020
Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis ...
Roshan Kamal Topno, Vidya Nand Rabi Das, Maneesh Kumar, Major Madhukar, Krishna Pandey, Neena Verma, Kanhaiya Agrawal, Chandra Shekhar Lal, Niyamat Ali Siddiqui, Sanjiva Bimal, Pradeep Das   +10 more
doaj   +1 more source

Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition

, 2021
: Background Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by an increasing treatment failure.
Dirkx, Laura, Caljon, Guy, Maes, Louis, Timmermans, Jean-Pierre, Van den Kerkhof, Magali, Van Bockstal, Lieselotte, Hendrickx, Sarah, De Trez, Carl, Bult\ue9, Dimitri   +8 more
core  

Estudo comparativo entre miltefosina oral e antimoniato de N-metil glucamina parenteral no tratamento da leishmaniose experimental causada por Leishmania (Leishmania) amazonensis Comparative study between oral miltefosine and parenteral N-metil glucamine antimoniate for the treatment of experimental leishmaniasis caused Leishmania (Leishmania) amazonensis

Revista da Sociedade Brasileira de Medicina Tropical, 2008
Vinte e cinco camundongos infectados com Leishmania amazonensis foram tratados com antimoniato de N-metil glucamina e miltefosina oral. Critérios: medidas das patas, pesquisa de amastigotas e culturas após-tratamento.
Arnoldo Velloso da Costa Filho, Íris Campos Lucas, Raimunda Nonata Ribeiro Sampaio   +2 more
doaj   +1 more source

[Miltefosine : a new remedy for leishmaniasis]

, 2006
There is a need for a safe and effective oral treatment for cutaneous and visceral leishmaniasis. Miltefosine is the first oral drug that is efficacious against different forms ofleishmaniasis, however it is not equally effective against all Leishmania ...
de Vries, P J, Dorlo, T P C, Beijnen, J H, Eggelte, T A   +3 more
core  

Oral miltefosine for refractory Acanthamoeba keratitis

American Journal of Ophthalmology Case Reports, 2019
Purpose: To report the first case of Acanthamoeba keratitis treated with oral miltefosine in the United States. Observations: A 17-year-old female with a history of orthokeratology contact lens wear presented after five months of left eye pain, redness ...
Kristin E. Hirabayashi, Charles C. Lin, Christopher N. Ta   +2 more
doaj   +1 more source

Efficacy of Miltefosine for the Treatment of American Cutaneous Leishmaniasis

, 2010
: Miltefosine is an oral agent used for cutaneous leishmaniasis treatment. An open-label, randomized, phase III clinical trial was carried out in the Colombian army population.
Carlos Rojas, Vélez Bernal, Iván Darío, Erwin Rodríguez, Rodríguez, Erwin, Ximena Sánchez, Rojas Arbeláez, Carlos Alberto, Sánchez, Ximena, Liliana López, Iván Vélez, Mestra Palomino, Laureano Alberto, Laureano Mestra, López Carvajal, Liliana   +11 more
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Understanding Miltefosine-Membrane Interactions using Molecular Dynamics Simulations [PDF]

, 2014
Coarse-grained molecular dynamics simulations are used to calculate the free energies of transfer of miltefosine, an alkylphosphocholine anticancer agent, from water to lipid bilayers to study its mechanism of interaction with biological membranes.
Vishnu Sresht (1615900), Carlota Oliveira Rangel-Yagui (1385172), Malta de Sa, Matheus, Rangel Yagui, Carlota Oliveira, Matheus Malta de Sá (1615903), Sresht, Vishnu, Blankschtein, Daniel, Daniel Blankschtein (1394725)   +7 more
core   +1 more source