Results 71 to 80 of about 10,985 (213)

Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025

HIV Medicine, Volume 27, Issue 1, Page 18-32, January 2026.
Abstract Background The European AIDS Clinical Society (EACS) guidelines were revised for the 21st time in 2025, with updates covering all aspects of HIV care. Key Points of the Guidelines Update The structure of the guidelines has been reorganized into two parts: Part I focuses on the management and prevention of HIV and related infections, and Part ...
Juan Ambrosioni, Laura I. Levi, Jasmini Alagaratnam, Abiu Sempere, Andrea Mastrangelo, Paolo Paioni, Cristina Mussini, Catia Marzolini, Susanne Dam Nielsen, Charles Béguelin, Steven Welch, Anna Koval, Luis Mendao, Alasdair Bamford, Alexandra Calmy, Giovanni Guaraldi, Cristiana Oprea, Esteban Martínez, Jürgen K. Rockstroh, The EACS Governing Board   +19 more
wiley   +1 more source

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum

Brazilian Journal of Infectious Diseases
OBJECTIVES: Apoptosis is the process of programmed cell death (PCD) that occurs in both animal and plant cells. Protozoan parasites possess metacaspase and these caspase-related proteases could be involved in the PCD pathways in these organisms ...
Shahram Khademvatan, Mohammad Javad Gharavi, Jasem Saki   +2 more
doaj   +1 more source

Severe post-kala-azar dermal leishmaniasis successfully treated with miltefosine in an Ethiopian HIV patient

International Journal of Infectious Diseases, 2019
Post-kala-azar dermal leishmaniasis (PKDL) is a neglected tropical disease characterized by a dermatosis which often appears after successful treatment of visceral leishmaniasis caused by Leishmania donovani.
Charles Abongomera, Tullia Battaglioli, Cherinet Adera, Koert Ritmeijer   +3 more
doaj   +1 more source

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs [PDF]

, 2018
Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures.
Aguado, Begoña, Camacho, Esther, Castanys, Santiago, Corvo, Laura, Dujardin, Jean Claude, Gamarro, Francisco, García-Hernández, Raquel, Imamura, Hideo, Rastrojo, Alberto, Requena, Jose M., Vargas, Paola   +10 more
core   +2 more sources

Identification of Potential Therapeutic Agents for Primary Amebic Meningoencephalitis Using Text Mining and Bioinformatics Analyses

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Naegleria fowleri, the brain‐eating ameba, causes primary amebic meningoencephalitis (PAM), a fatal infectious disease that affects the central nervous system (CNS). We aimed to evaluate the functions and potential drugs targeting PAM using text mining and bioinformatics analyses.
Eun Jung Sohn, Hyeonseo Jo, Kun Taek Park, Andrey Elchaninov   +3 more
wiley   +1 more source

Miltefosine reinvigorates exhausted T cells by targeting their bioenergetic state

Cell Reports Medicine
Summary: T cell exhaustion presents a major challenge for the efficacy of both immune checkpoint inhibitors (ICBs) and chimeric antigen receptor T (CAR-T) cell immunotherapies.
Xingying Zhang, Chenze Zhang, Shan Lu, Jingxi Dong, Na Tang, Yao Wang, Weidong Han, Xi Pan, Xiang Zhang, Duan Liu, Ng Shyh-Chang, Yu Wang, Guihai Feng, Haoyi Wang   +13 more
doaj   +1 more source

Liposomal amphotericin B for visceral leishmaniasis in human immunodeficiency virus-coinfected patients: 2-year treatment outcomes in Bihar, India [PDF]

, 2011
Reports on treatment outcomes of visceral leishmaniasis (VL)-human immunodeficiency virus (HIV) coinfection in India are lacking. To our knowledge, none have studied the efficacy of liposomal amphotericin B in VL-HIV coinfection.
Alvar, Bachani, Berman, Bern, Bora, Braitstein, C. Ferreyra, D. Remartinez, G. Mitra, Hurissa, Ikomi, J. van Griensven, K. Pandey, L. Flevaud, Lin, Lyons, M. Pece, Mathur, N. Kumar, N. Verma, P. Das, P. K. Sinha, P. Kumar, P. P. Palma, Pintado, R. Kumar, R. Mahajan, Redhu, Sinha, Sinha, Sundar, Sundar, ter Horst, Thakur, van Griensven   +34 more
core   +2 more sources

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

Lipids in Health and Disease, 2010
The alkylphospholipid analog miltefosine (hexadecylphosphocholine) is a membrane-directed antitumoral and antileishmanial drug belonging to the alkylphosphocholines, a group of synthetic antiproliferative agents that are promising candidates in ...
Segovia Josefa L, Marco Carmen, Ríos-Marco Pablo, Jiménez-López José M, Carrasco María P   +4 more
doaj   +1 more source

Inefficacy of the association N-methyl glucamine and topical miltefosine in the treatment of experimental cutaneous leishmaniasis by Leishmania (Leishmania) amazonensis

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Pentavalent antimonial (SbV) is the first treatment for cutaneous leishmaniasis (CL). Other drugs present similar side effects and higher cost. Oral miltefosine is effective to treat kala-azar.
R. N. R. Sampaio, I. C. Lucas, H. L. Takami   +2 more
doaj   +1 more source

Use of miltefosine in the treatment of visceral leishmaniasis in children at a tertiary care hospital of Karachi [PDF]

, 2010
Existing standard treatment options for visceral leishmaniasis are less than optimal. We report here the use of oral miltefosine in the treatment of two paediatric cases of visceral leishmaniasis at a tertiary care hospital in Karachi, Pakistan.
Humayun, Khadija Nuzhat, Jehan, Fyezah, Khalid, Umair, Saleem, Taimur, Soofi, Sajid   +4 more
core   +1 more source