Results 71 to 80 of about 8,155 (173)

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum

Brazilian Journal of Infectious Diseases, 2011
Objectives: Apoptosis is the process of programmed cell death (PCD) that occurs in both animal and plant cells. Protozoan parasites possess metacaspase and these caspase-related proteases could be involved in the PCD pathways in these organisms ...
Shahram Khademvatan, Mohammad Javad Gharavi, Jasem Saki   +2 more
doaj   +1 more source

Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe, Vishal Satikuvar, Tanjia M. Syeda, Monica Cal, Pascal Mäser, Marcel Kaiser, Hachemi Kadri   +6 more
wiley   +1 more source

Deletion of the miltefosine transporter.

, 2019
A) Genome coverage at the transporter locus. Normalised mapped read count for 100 bp windows is plotted against genomic position on chromosome 13 (normalisation was achieved by adjusting counts by the ratio between total mapped read counts for chromosome
Paul A. Bates (126749), Andrew W. Pountain (4114570), Clément Regnault (6293867), Stefan K. Weidt (702682), Nicholas J. Dickens (268234), Anne M. Donachie (176370), Michael P. Barrett (167748)   +6 more
core   +1 more source

Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum

Brazilian Journal of Infectious Diseases
OBJECTIVES: Apoptosis is the process of programmed cell death (PCD) that occurs in both animal and plant cells. Protozoan parasites possess metacaspase and these caspase-related proteases could be involved in the PCD pathways in these organisms ...
Shahram Khademvatan, Mohammad Javad Gharavi, Jasem Saki   +2 more
doaj   +1 more source

Severe post-kala-azar dermal leishmaniasis successfully treated with miltefosine in an Ethiopian HIV patient

International Journal of Infectious Diseases, 2019
Post-kala-azar dermal leishmaniasis (PKDL) is a neglected tropical disease characterized by a dermatosis which often appears after successful treatment of visceral leishmaniasis caused by Leishmania donovani.
Charles Abongomera, Tullia Battaglioli, Cherinet Adera, Koert Ritmeijer   +3 more
doaj   +1 more source

Miltefosine as a novel influenza vaccine adjuvant

, 2020
Vaccine plays a major role in the prevention of influenza virus infection. However, the effectiveness of currently available influenza vaccines is unsatisfactory.
Lu, Lu, 盧璐
core  

Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis

مجله دانشکده پزشکی اصفهان, 2014
Background: Due to the limited number of studies, failure to adequately investigating the impact of miltefosine in the treatment of cutaneous leishmaniasis, and the fact that faster recovery of injuries causes less scarring for the patient, the present ...
Ali Asilian, Shaghayegh Omrani, Mohammad Ail Nilforoushzadeh   +2 more
doaj  

Miltefosine reinvigorates exhausted T cells by targeting their bioenergetic state

Cell Reports Medicine
Summary: T cell exhaustion presents a major challenge for the efficacy of both immune checkpoint inhibitors (ICBs) and chimeric antigen receptor T (CAR-T) cell immunotherapies.
Xingying Zhang, Chenze Zhang, Shan Lu, Jingxi Dong, Na Tang, Yao Wang, Weidong Han, Xi Pan, Xiang Zhang, Duan Liu, Ng Shyh-Chang, Yu Wang, Guihai Feng, Haoyi Wang   +13 more
doaj   +1 more source

Inefficacy of the association N-methyl glucamine and topical miltefosine in the treatment of experimental cutaneous leishmaniasis by Leishmania (Leishmania) amazonensis

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Pentavalent antimonial (SbV) is the first treatment for cutaneous leishmaniasis (CL). Other drugs present similar side effects and higher cost. Oral miltefosine is effective to treat kala-azar.
R. N. R. Sampaio, I. C. Lucas, H. L. Takami   +2 more
doaj   +1 more source

Trial of oral miltefosine for visceral leishmaniasis

, 1998
Background: There is no effective oral treatment for visceral leishmaniasis (kala-azar), a disseminated intracellular protozoal infection that occurs worldwide.
Voss, Andreas, Mandal, Ashim K., Murray, Henry W., Rosenkaimer, Frank, Sundar, Shyam, Makharia, Manoj K., Hilgard, Peter, Goyal, Ashish K.   +7 more
core   +1 more source