Results 61 to 70 of about 8,155 (173)

Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure‐Guided Inhibitor Identification and Biochemical Validation

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Structure‐guided and biochemical analyses indicate that DNA primase of Leishmania donovani represents a potential therapeutic target, as repurposed compounds, particularly Pritelivir, demonstrate marked inhibitory effects accompanied by reduced parasite proliferation, replication, and altered cellular morphology in in vitro and cell‐based studies ...
Deep Bhowmik, Anupama Sharma, Ravi Prakash Arya, Diwakar Kumar   +3 more
wiley   +1 more source

Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients

, 2008
The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent, unknown. We examined and characterized the pharmacokinetics of miltefosine in a group of patients with Old World (Leishmania major) cutaneous leishmaniasis. Miltefosine
Huitema, Alwin D R, Beijnen, Jos H., van Thiel, Pieter P A M, van Thiel, Pieter P. A. M., de Vries, Peter J, Huitema, Alwin D. R., Keizer, Ron J., de Vries, Henry J C, de Vries, Henry J. C., de Vries, Peter J., Dorlo, Thomas P. C., Dorlo, Thomas P C, Beijnen, Jos H, Keizer, Ron J   +13 more
core   +1 more source

A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasisResearch in context

EBioMedicine, 2018
Background: Miltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL in a clinical trial in Brazil.
Juliana B.T. Carnielli, Kathryn Crouch, Sarah Forrester, Vladimir Costa Silva, Sílvio F.G. Carvalho, Jeziel D. Damasceno, Elaine Brown, Nicholas J. Dickens, Dorcas L. Costa, Carlos H.N. Costa, Reynaldo Dietze, Daniel C. Jeffares, Jeremy C. Mottram   +12 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Evaluation of the Cutaneous Immunological Milieu Before and After Treatment With Meglumine Antimoniate in Dogs Naturally Affected by Leishmaniosis due to Leishmania infantum

Veterinary Dermatology, Volume 37, Issue 3, Page 455-463, June 2026.
Background: Canine leishmaniosis (CanL) is a zoonotic disease of variable severity. The typical immune response is driven by an exaggerated humoral immune response. Protective immunity is mediated by pro‐inflammatory cytokines that enhance macrophage leishmanicidal activity. Objective: To evaluate the cutaneous and the systemic immune responses as well
M. Platenik, A. Di Loria, L. Archer, M. Saridomichelakis, A. S. Benvenuto, D. Santoro   +5 more
wiley   +1 more source

Comparison of the end-of-treatment miltefosine plasma concentrations between body weight categories.

, 2016
The left plot shows the AmBisome + miltefosine arm (10 days of miltefosine), the right plot the miltefosine alone arm (28 days of miltefosine).
Monique Wasunna (157135), Fabiana Alves (217602), Neal Alexander (18417), Thomas P. C. Dorlo (321337), Sally Ellis (157129), Eltahir Awad Gasim Khalil (3119940), Susan Wells (3119952), Rashid Juma (463480), Anke E. Kip (3119949), Joseph Olobo (156982), Simon Njenga (3119955), Gerard J. Schoone (244545), Manica Balasegaram (156987), Nathalie Strub Wourgaft (3119943), George Kirigi (157066), Robert Kimutai (157106), Raymond Omollo (156992), Asrat Hailu (59005), Mohammed Hassan Sharaf Ali (3119958), Mohammed Yasein Elamin (3119946), Brima Musa (157009), Ahmed Musa (156973), Tansy Edwards (122527)   +22 more
core   +1 more source

In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari, Mohammad Reza Youssefi, Mohaddeseh Abouhosseini Tabari   +2 more
wiley   +1 more source

Hypothetical diagram of lipid nanocapsules incorporating miltefosine.

, 2015
Hypothetical diagram of lipid nanocapsules incorporating miltefosine.
Labiba K. El-Khordagui (827790), Mervat Z. El-Azzouni (827789), Maha M. Eissa (827785), Eglal I. Amer (827788), Riham M. El-Moslemany (827786), Alyaa A. Ramadan (827787)   +5 more
core   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

Miltefosine Impacts Small Molecule Transport in Gram-Positive Bacteria [PDF]

Miltefosine (MLT) is an alkylphosphocholine with clinical success as an anticancer and antiparasitic drug. Although the mechanism of action of MLT is highly debated, the interaction of MLT with the membrane, specifically lipid rafts of eukaryotes, is ...
Tessa, Calhoun, Marea, Blake, Eleanor, Page, Madeline, Smith   +3 more
core   +1 more source