Results 41 to 50 of about 8,155 (173)

Biological Evaluation, Molecular Docking, MD Simulation Study and Synthesis of (Z)‐N’‐(3‐phenoxybenzylidene)‐2‐(substituted‐amino aryl) Acetohydrazid

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Synthesis and biological evaluation (antibacterial, antifungal, anti‐tuberculosis, antiprotozoal) and in silico molecular docking of biphenyl ether based Schiff's base analogues. ABSTRACT In order to investigate their possible biological activity, a number of new Schiff base compounds based on diaryl ether, specifically 2‐(substituted‐arylamino)‐N′‐(3 ...
Navin B. Patel, Deepti S. Ghaisas, Vatsal M. Patel, Faiyazalam M. Shaiikh, Mohit Agrawal, Mohd Imran, Gildardo Rivera, Hetal I. Soni   +7 more
wiley   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Beyond the Active Site: First‐In‐Class Leishmania Infantum Trypanothione Reductase Dimerization Disruptors as Antileishmanial Leads

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
This review outlines a pioneering strategy to inhibit Leishmania infantum trypanothione reductase by disrupting its dimer interface. From peptides to small‐molecule proteomimetics, multiple chemotypes achieved potent enzymatic inhibition and notable cellular antileishmanial activity, highlighting a new therapeutic paradigm.
María‐José Camarasa, Miguel Maldonado, Alvaro de la Cruz‐Potenciano, Sonia de Castro   +3 more
wiley   +1 more source

Isobologram analysis for the combinations between BT06 and miltefosine (A) and AB13 and miltefosine (B).

, 2014
The line indicates synergy, additivity or antagonism when the points are located below, on or above the line, respectively. (a) derivative and 2 µM miltefosine; (b) derivative and 4 µM miltefosine; (c) derivative and 6 µM miltefosine.
Rita C. Santos (538877), Manuel Santos-Rosa (538878), Maria C. Sousa (538875), Raquel Varandas (538876), Vera Alves (538879), Jorge A. R. Salvador (538880)   +5 more
core   +1 more source

Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition

Frontiers in Immunology, 2018
Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules.
Zuzana Rubíková, Vadym Sulimenko, Tomáš Paulenda, Pavel Dráber   +3 more
doaj   +1 more source

Benzophenone Derivatives as a New Class of Anti‐Infectives Against Acanthamoeba spp

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Analogues of the human oxidosqualene cyclase inhibitor Ro 48‐8071 were designed, synthesized, and tested against Acanthamoeba hatchetti, one of the pathogens causing Acanthamoeba keratitis. The N‐propargyl derivative 4f showed strong amoebicidal activity with complete eradication of trophozoites and cysts, while exhibiting low toxicity toward human ...
Tomas Rimkus, Hannes Geisler, Taha B. El‐Jourani, Aurélien F. A. Moumbock, Matthias Schiedel, Stephan Reichl   +5 more
wiley   +1 more source

Repurposing miltefosine for the treatment of immune-mediated disease? [PDF]

, 2014
Miltefosine is an ether lipid that was initially developed for cancer treatment in the early 1980s. Miltefosine largely failed development for oncology, although it was approved for the topical treatment of breast cancer metastasis.
Wildenberg, ME, Peppelenbosch, Maikel, Hommes, DW, Wildenberg, M.E., Verhaar, A.P., Hommes, D.W., Verhaar, Auke, Peppelenbosch, M.P., Wildenberg, Manon E., van den Brink, GR, van den Brink, Gijs R., Brink, G.R. van den, Hommes, Daniel W., Peppelenbosch, Maikel P., Verhaar, Auke P.   +14 more
core   +1 more source

Resolution of Acanthamoeba Keratitis with Adjunctive Use of Oral Miltefosine

, 2021
Purpose: To report a series of cases demonstrating the resolution of Acanthamoeba keratitis (AK) with adjunctive use of oral miltefosine. Methods: Retrospective case series.
Avdagic, Ema, Doshi, Rutvi, Chew, Hall F., Tu, Elmer Y., Boggild, Andrea K., Farooq, Asim V., Veldman, Peter, Reidy, James J., Jafri, Mansab   +8 more
core   +1 more source

Dicentrine, an Aporphine Alkaloid From Ocotea langsdorffii, Induces Mitochondrial Dysfunction and Oxidative Stress in Leishmania (L.) infantum

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Dicentrine, an aporphine alkaloid, exhibits potent in vitro antileishmanial activity against Leishmania species with high selectivity and low macrophage cytotoxicity. Mechanistic studies reveal that the compound triggers parasite death possibly by inducing mitochondrial membrane disruption and oxidative stress.
Camila S. de Freitas, Eduardo Oliveira S. da Silva, Daniela C. Tristão, Guilherme M. Antar, Daniela P. Lage, Dóris M. Abrão, Luciana M. Ribeiro Antinarelli, Elaine S. Coimbra, João Henrique G. Lago, Eduardo A. F. Coelho   +9 more
wiley   +1 more source

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source