Results 31 to 40 of about 8,155 (173)

Antimony susceptible Leishmania donovani: evidence from in vitro drug susceptibility of parasites isolated from patients of post-kala-azar dermal leishmaniasis in pre- and post-miltefosine era

Microbiology Spectrum
Post-kala-azar dermal leishmaniasis (PKDL) patients are a key source of Leishmania donovani parasites, hindering the goal of eliminating visceral leishmaniasis (VL). Monitoring treatment response and parasite susceptibility is essential due to increasing
Sushmita Ghosh, Aditya Verma, Dhiraj Kumar, Deepak Kumar Deep, V. Ramesh, Poonam Salotra, Ruchi Singh   +6 more
doaj   +1 more source

Lipid raft‐disrupting miltefosine preferentially induces the death of colorectal cancer stem‐like cells

Clinical and Translational Medicine, 2021
Background Lipid rafts (LRs), cholesterol‐enriched microdomains on cell membranes, are increasingly viewed as signalling platforms governing critical facets of cancer progression.
So‐Yeon Park, Jee‐Heun Kim, Jang‐Hyun Choi, Choong‐Jae Lee, Won‐Jae Lee, Sehoon Park, Zee‐Yong Park, Jeong‐Heum Baek, Jeong‐Seok Nam   +8 more
doaj   +1 more source

Miltefosine: issues to be addressed in the future.

, 2006
Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice ...
Berman, J, Croft, S, Sundar, S, Bryceson, ADM, Bryceson, A. D. M., Karbwang, J, Sindermann, H, Berman, J., Engel, J., Urbina, J. A., Gutteridge, W, Engel, J, Croft, S., Gutteridge, W., Karbwang, J., Soto, J., Soto, J, Urbina, JA, Sindermann, H., Sundar, S.   +19 more
core   +1 more source

Miltefosine induces programmed cell death in Leishmania amazonensis promastigotes [PDF]

, 2011
In the current study, we evaluated the mechanism of action of miltefosine, which is the first effective and safe oral treatment for visceral leishmaniasis, in Leishmania amazonensis promastigotes. Miltefosine induced a process of programmed cell death,
Gonçalves, Keyla Cristiny da Silva, Oliveira, Ana Carolina de Siqueira Couto de, Bellio, Maria, Oliveira, Selma Soares de, Marinho, Fernanda de Aquino, Santos, André Luis Souza dos, Levy, Claudia Masini d'Avila, Branquinha, Marta Helena   +7 more
core   +5 more sources

Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India.

, 2004
Miltefosine has previously been shown to cure 97% of cases of visceral leishmaniasis (VL) in Indian adults. Because approximately one-half of cases of VL occur in children, we evaluated use of the adult dosage of miltefosin (2.5 mg/kg per day for 28 days)
Thakur, C. P., Junge, Klaus, Bhattacharya, Sujit K., Thakur, CP, Berman, Jonathan D, Bryceson, Anthony D. M., Jha, T. K., Bhattacharya, Sujit K, Bryceson, Anthony DM, Berman, Jonathan D., Sundar, Shyam, Karbwang, Juntra, Engel, Juergen, Sindermann, Herbert, Jha, TK   +14 more
core   +1 more source

Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial.

PLoS Neglected Tropical Diseases, 2016
BackgroundSSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization.
Monique Wasunna, Simon Njenga, Manica Balasegaram, Neal Alexander, Raymond Omollo, Tansy Edwards, Thomas P C Dorlo, Brima Musa, Mohammed Hassan Sharaf Ali, Mohammed Yasein Elamin, George Kirigi, Rashid Juma, Anke E Kip, Gerard J Schoone, Asrat Hailu, Joseph Olobo, Sally Ellis, Robert Kimutai, Susan Wells, Eltahir Awad Gasim Khalil, Nathalie Strub Wourgaft, Fabiana Alves, Ahmed Musa   +22 more
doaj   +1 more source

Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.

PLoS Neglected Tropical Diseases, 2017
BackgroundOral miltefosine has been shown to be non-inferior to first-line, injectable meglumine antimoniate (MA) for the treatment of cutaneous leishmaniasis (CL) in children.
Brandon A Berger, Alexandra Cossio, Nancy Gore Saravia, Maria Del Mar Castro, Sergio Prada, Allison H Bartlett, Mai T Pho   +6 more
doaj   +1 more source

Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.

PLoS Neglected Tropical Diseases, 2010
BackgroundCutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance.Methodology/principal ...
Paulo R Machado, Julia Ampuero, Luiz H Guimarães, Leonardo Villasboas, Ana T Rocha, Albert Schriefer, Rosana S Sousa, Anette Talhari, Gerson Penna, Edgar M Carvalho   +9 more
doaj   +1 more source

Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg, Dennis Wienand, Lucie Harpain, Marie‐Luise Brunner‐Kovarik, Julia Walochnik, Markus Wiesmueller, Amélie Hampel, Tibor Spath, Lukas Trnka, Judit Simon, Alessandra Handisurya   +10 more
wiley   +1 more source

The zinc cluster transcription factor Znc1 regulates Rta3-dependent miltefosine resistance in Candida albicans

mSphere
Zinc cluster transcription factors (ZCFs) are a family of transcription regulators that are almost exclusively found in the fungal kingdom. Activating mutations in the ZCFs Mrr1, Tac1, and Upc2 frequently cause acquired resistance to the widely used ...
Bernardo Ramírez-Zavala, Ines Krüger, Sonja Schwanfelder, Katherine S. Barker, P. David Rogers, Joachim Morschhäuser   +5 more
doaj   +1 more source