Results 31 to 40 of about 5,633 (170)
Veterinary Dermatology, Volume 37, Issue 3, Page 455-463, June 2026.Background: Canine leishmaniosis (CanL) is a zoonotic disease of variable severity. The typical immune response is driven by an exaggerated humoral immune response. Protective immunity is mediated by pro‐inflammatory cytokines that enhance macrophage leishmanicidal activity. Objective: To evaluate the cutaneous and the systemic immune responses as well
M. Platenik +5 more
wiley +1 more source
In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome
Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari +2 more
wiley +1 more source
Frontiers in Immunology, 2018 Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules.
Zuzana Rubíková +3 more
doaj +1 more source
Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review
Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira +3 more
wiley +1 more source
Targeting Kinetoplastid Parasites with ProTide Prodrugs: A Proof‐of‐Concept Study
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Neglected tropical diseases (NTDs) remain a major global health challenge, particularly in low‐ and middle‐income countries. Kinetoplastid parasites causing Chagas disease, leishmaniasis, and African trypanosomiasis rely on host purine salvage pathways, making nucleoside analogues attractive therapeutic candidates.
Silvester Lowe +6 more
wiley +1 more source
Investigation of in vitro Efficacy of Miltefosine on Chronic Cutaneous Leishmaniasis
Türkiye Parazitoloji Dergisi, 2022 Objective:Leishmaniasis is the second deadliest parasitic disease in the World Health Organisation’s list of neglected diseases, following malaria. Cutaneous leishmaniasis (CL) is the most common form of the disease and it is one of the few communicable ...
Varol Tunalı +5 more
doaj +1 more source
Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors
Advanced Science, Volume 13, Issue 21, 13 April 2026.A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1087-1097, April 2026.Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon +12 more
wiley +1 more source
Miltefosine: A Repurposing Drug against Mucorales Pathogens
Journal of Fungi, 2023 Mucorales are a group of non-septated filamentous fungi widely distributed in nature, frequently associated with human infections, and are intrinsically resistant to many antifungal drugs.
Mariana Ingrid Dutra da Silva Xisto +9 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou +9 more
wiley +1 more source