Results 31 to 40 of about 10,985 (213)

Miltefosine [PDF]

Reactions Weekly, 2020
Ramy H. Elshaboury, Ronak G. Gandhi
  +5 more sources

Antimony susceptible Leishmania donovani: evidence from in vitro drug susceptibility of parasites isolated from patients of post-kala-azar dermal leishmaniasis in pre- and post-miltefosine era

Microbiology Spectrum
Post-kala-azar dermal leishmaniasis (PKDL) patients are a key source of Leishmania donovani parasites, hindering the goal of eliminating visceral leishmaniasis (VL). Monitoring treatment response and parasite susceptibility is essential due to increasing
Sushmita Ghosh, Aditya Verma, Dhiraj Kumar, Deepak Kumar Deep, V. Ramesh, Poonam Salotra, Ruchi Singh   +6 more
doaj   +1 more source

Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model. [PDF]

, 2016
UNLABELLED: Cutaneous leishmaniasis (CL) is caused by several species of the protozoan parasite Leishmania and affects approximately 10 million people worldwide.
Croft, Simon L, Murdan, Sudaxshina, Van Bocxlaer, Katrien, Yardley, Vanessa   +3 more
core   +2 more sources

Cost-effectiveness of meglumine antimoniate versus miltefosine caregiver DOT for the treatment of pediatric cutaneous leishmaniasis.

PLoS Neglected Tropical Diseases, 2017
BackgroundOral miltefosine has been shown to be non-inferior to first-line, injectable meglumine antimoniate (MA) for the treatment of cutaneous leishmaniasis (CL) in children.
Brandon A Berger, Alexandra Cossio, Nancy Gore Saravia, Maria Del Mar Castro, Sergio Prada, Allison H Bartlett, Mai T Pho   +6 more
doaj   +1 more source

Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial.

PLoS Neglected Tropical Diseases, 2010
BackgroundCutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance.Methodology/principal ...
Paulo R Machado, Julia Ampuero, Luiz H Guimarães, Leonardo Villasboas, Ana T Rocha, Albert Schriefer, Rosana S Sousa, Anette Talhari, Gerson Penna, Edgar M Carvalho   +9 more
doaj   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

The zinc cluster transcription factor Znc1 regulates Rta3-dependent miltefosine resistance in Candida albicans

mSphere
Zinc cluster transcription factors (ZCFs) are a family of transcription regulators that are almost exclusively found in the fungal kingdom. Activating mutations in the ZCFs Mrr1, Tac1, and Upc2 frequently cause acquired resistance to the widely used ...
Bernardo Ramírez-Zavala, Ines Krüger, Sonja Schwanfelder, Katherine S. Barker, P. David Rogers, Joachim Morschhäuser   +5 more
doaj   +1 more source

Evaluation of the Cutaneous Immunological Milieu Before and After Treatment With Meglumine Antimoniate in Dogs Naturally Affected by Leishmaniosis due to Leishmania infantum

Veterinary Dermatology, EarlyView.
Background: Canine leishmaniosis (CanL) is a zoonotic disease of variable severity. The typical immune response is driven by an exaggerated humoral immune response. Protective immunity is mediated by pro‐inflammatory cytokines that enhance macrophage leishmanicidal activity. Objective: To evaluate the cutaneous and the systemic immune responses as well
M. Platenik, A. Di Loria, L. Archer, M. Saridomichelakis, A. S. Benvenuto, D. Santoro   +5 more
wiley   +1 more source

In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari, Mohammad Reza Youssefi, Mohaddeseh Abouhosseini Tabari   +2 more
wiley   +1 more source

A dose-finding study of miltefosine (hexadecylphosphocholine) in patients with metastatic solid tumours [PDF]

, 1992
The ether lipid miltefosine (hexadecylphosphocholine) was orally given to patients with various tumours in a dose-finding study. All patients initially received a daily total dose of 100 mg, which in the absence of side-effects was increased to 150 mg ...
Burg, M.E.L. (Maria) van der, Planting, A.S.Th. (André), Stoter, G. (Gerrit), Verweij, J. (Jaap)   +3 more
core   +1 more source