Results 11 to 20 of about 8,155 (173)

Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl/6 mice [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 2014
Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline.
Ana Angélica Amorim Santarem, Gabriel Frizon Greggianin, Rafaela Garcia Debastiani, Jefferson Bruno Pereira Ribeiro, Demerson Andre Polli, Raimunda Nonata Ribeiro Sampaio   +5 more
doaj   +2 more sources

The in vitro leishmanicidal activity of hexadecylphosphocholine (miltefosine) against four medically relevant Leishmania species of Brazil

Memorias do Instituto Oswaldo Cruz, 2011
The in vitro leishmanicidal activity of miltefosine® (Zentaris GmbH) was assessed against four medically relevant Leishmania species of Brazil: Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, Leishmania (Viannia) guyanensis and ...
Eliane de Morais-Teixeira, Quesia Souza Damasceno, Mariana Kolos Galuppo, Alvaro José Romanha, Ana Rabello   +4 more
doaj   +4 more sources

Pyridyl-Thiazole-Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling. [PDF]

ChemMedChem
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Silva AJFSD, Olimpio DSDC, Sousa LMDS, Brondani GL, Silva TL, Silva WBL, Costa NTC, Hernandes MZ, Junior PAS, Pereira VRA, Leite ACL.   +10 more
europepmc   +2 more sources

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis. [PDF]

Chem Biol Drug Des
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Jacques Dit Lapierre TJW, Gabriela Faleiro de Moura Lodi Cruz M, Freitas de Lima Hercos G, Chelucci RC, Michelan-Duarte S, Barbosa G, Costa AR, Chávez-Fumagalli MA, Derksen Macruz P, Jorge Pilau E, Ferreira LLG, Andricopulo AD, Maria Fonseca Murta S, de Oliveira Rezende Júnior C.   +13 more
europepmc   +2 more sources

Oral miltefosine for Indian visceral leishmaniasis. [PDF]

, 2002
BACKGROUND: There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost all untreated patients die, and all the effective agents have been parenteral.
Berman, Jonathan, Thakur, C. P., Sundar, Shyam, Junge, Klaus, Thakur, CP, Bryceson, Anthony, Engel, Juergen, Sindermann, Herbert, Jha, TK, Jha, T. K., Fischer, Christina   +10 more
core   +1 more source

Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine

mBio, 2021
Aspergillus fumigatus is an important fungal pathogen and the main etiological agent of aspergillosis, a disease characterized by a noninvasive process that can evolve to a more severe clinical manifestation, called invasive pulmonary aspergillosis (IPA),
Thaila Fernanda dos Reis, Maria Augusta Crivelente Horta, Ana Cristina Colabardini, Caroline Mota Fernandes, Lilian Pereira Silva, Rafael Wesley Bastos, Maria Vitória de Lazari Fonseca, Fang Wang, Celso Martins, Márcio L. Rodrigues, Cristina Silva Pereira, Maurizio Del Poeta, Koon Ho Wong, Gustavo H. Goldman   +13 more
doaj   +1 more source

A Comparison of Miltefosine and Sodium Stibogluconate for Treatment of Visceral Leishmaniasis in an Ethiopian Population with High Prevalence of HIV Infection. [PDF]

, 2006
BACKGROUND: Antimonials are the mainstay of visceral leishmaniasis (VL) treatment in Africa. The increasing incidence of human immunodeficiency virus (HIV) coinfection requires alternative safe and effective drug regimens.
Dejenie, A, Hundie, T B, Boots, G, Davidson, R N, Assefa, Y, den Boer, M, Ritmeijer, K, Mesure, J   +7 more
core   +1 more source

A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B [PDF]

, 2023
A male rural worker with cutaneous leishmaniasis (CL) was initially treated with repeated cycles of Meglumine Antimoniate (Glucantime®) and two cycles of Amphotericin B deoxycholate during a three-year period.
Olivera, Maria Eugenia, Papera, Francesca, Manuela Bono, María Eugenia Olivera, Bono, Manuela, Francesca Papera, Elvia Mejía, Lauthier, Juan José, Barroso, Paola Andrea, Guzman, Maria Laura, María Florencia Peralta, Peralta, Maria Florencia, Paola Andrea Barroso, Juan José Lauthier, Dolores Catalina Carrer, María Laura Guzman, Marcelo Quipildor, Carrer, Dolores Catalina, Quipildor, Marcelo Omar, Mejía Montaño, Elvia   +19 more
core   +1 more source

Evaluation of the Ability of Miltefosine Associated with Topical GM-CSF in Modulating the Immune Response of Patients with Cutaneous Leishmaniasis

Journal of Immunology Research, 2020
Cutaneous leishmaniasis (CL) due to L. braziliensis is associated with an exaggerated inflammatory response and tissue damage. Miltefosine is more effective than pentavalent antimony (Sbv) in the treatment of CL, and here, we evaluate the ability of Sbv,
Fábio Peixoto, Maurício T. Nascimento, Rúbia Costa, Juliana Silva, Gaby Renard, Luiz Henrique Guimarães, Gerson Penna, Manoel Barral-Netto, Lucas P. Carvalho, Paulo R. L. Machado, Edgar M. Carvalho   +10 more
doaj   +1 more source

Antitumour activity of miltefosine alone and after combination with platinum complexes on MXT mouse mammary carcinoma models [PDF]

, 1993
Miltefosine, an alkylphosphocholine structurally related to alkyllysophospholipids showed highly selective antitumour activity against the hormone-sensitive variant of the s.c.
Spruß, Thilo, Engel, Jürgen, Schönenberger, Helmut, Bernhardt, Günther   +3 more
core   +1 more source