Results 121 to 130 of about 1,063,820 (299)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Economic Performance in Alberta Dairy: An Application of the Mimic Model [PDF]
Dairy production at the farm-level is undergoing a rapid transformation in preparation for more open competition in the future. However, the means by which dairy farms can best improve their economic performance is of some question.
Jeffrey, Scott R., Richards, Timothy J.
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Print Advertisement Characteristics and Apple Variety Attraction: A Mimic Model Approach [PDF]
A structural latent variable model of apple variety demand is used to analyze the effect of variety specific newspaper advertisement characteristics on variety attraction (preferences), and in turn on variety demand.
Patterson, Paul M., Richards, Timothy J.
core +1 more source
Hamiltonian Theory of Disorder at 1/3
, 2009 The Hamiltonian Theory of the fractional quantum Hall (FQH) regime provides a simple and tractable approach to calculating gaps, polarizations, and many other physical quantities. In this paper we include disorder in our treatment, and show that a simple
Murthy, Ganpathy
core +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Solar Neutrino Matter Effects Redux
, 2011 Following recent low-threshold analysis of the Sudbury Neutrino Observatory and asymmetry measurements of the BOREXINO Collaboration of the solar neutrino flux, we revisit the analysis of the matter effects in the Sun.
A. B. Balantekin +3 more
core +1 more source
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Payesh, 2022 Objective(s): It is believed that frequent use of Interne might be harmful for health. The Internet Addiction Test (IAT) is one of the most practical tools for diagnosing Internet addiction.
Fatemeh Askarian +3 more
doaj
Satisfaction in life conditions and well-being [PDF]
In this note we focus on the relations between analytical life satisfaction measures and a general well-being indicator, measured by the two general subjective well-being (SWB) questions.
DICKES Paul, KLEIN Carlo
core +1 more source