Results 141 to 150 of about 10,558 (304)
Kemess South Mine reclamation and closure
, 2010 The general reclamation strategy for the Kemess South Mine site marries long-term erosion control with successional reclamation principles. For disturbed areas, this requires proper preparation of surfaces, application of growth media, and ...
Evans, Jordan +3 more
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
, 1999 In the past few years, numerous mine closure and reclamation projects have been subjected to the provincial Contaminated Sites Regulation (CSR) in British Columbia. A mine decommissioning and closure plan should contain among other things a Detailed Site
Willmer, Bruce A., Mchaina, David Mhina
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Cost effective closure plan management for metal mines
, 1992 High closure costs have been incurred by some mines because of the failure to identify and mitigate conditions which require costly remediation on mine closure.
Robertson, A. MacG. +2 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Mine Closure 2019 Volume II. Proceedings of the 13th International Conference on Mine Closure
, 2019 The Thirteenth International Conference on Mine Closure returns to Perth, Australia where it was first held in 2006. Since then Mine Closure has become a necessary focus of mining and, with a global revival in the mining industry, the topic of Mine ...
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