Results 131 to 140 of about 10,558 (304)
, 2023 Under the Health, Safety and Reclamation Code for Mines in British Columbia (the Code), mines are required to submit updated Mine Plan and Reclamation Program Updates (5 Year Mine Update) to the BC Ministry of Energy, Mines and Low Carbon Innovation ...
Antill, Tim, Stevens, Victoria
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Mine closure planning at Equity Silver Mines Ltd.
, 1992 Equity Silver Mines Ltd. has scheduled pit closure by the third quarter of 1992. In preparation for this event, detailed plans have been developed to insure there is a smooth transition for release of the workforce and that environmental concerns are ...
Patterson, Robert J.
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Adaptive risk management and lessons learned : post-closure at the "mighty" Sullivan mine
, 2015 The Sullivan mine in Kimberley, British Columbia, operated for almost 100 years and was one of the world’s largest producers of lead, zinc and silver. Environmental and risk management controls were initiated in the 1960s, including construction in 1979 ...
Unger, M. L. +2 more
core
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesBodovalle is a siderite mine located in northern Spain that is currently in the closure phase. The mine was exploited using the room-and-pillar method.
Emilio Trigueros +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Underground Mine Rehabilitation for Closure : A Uranium Case Study
, 2019 Historical mine sites pose multiple challenges for final closure. Environmental legacies are a common area of concern, but physical stability of the site is equally important for a long-term, walk away solution.
Crossley, Chloe, Longo, Sue
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source