Results 121 to 130 of about 10,558 (304)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Hydrologic closure of mine tailings facilities
, 2011 This paper presents a hydrologic closure design concept to minimize the risk of water discharges from closed mine tailings facilities. It evaluates the applicability of U.S. Nuclear Regulatory Commission guidelines to develop acceptable designs for the
Denherder, Rod +4 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Settlement Patterns at Ok Tedi-stakeholders, 'corner' settlers and invaders
, 2020 Ok Tedi is a large open cut mine nestled away in a far off corner of Papua New Guinea. It is scheduled to close in 2013. Since Ok Tedi is such an important part of the regional economy, its supporting town has drawn many people from the surrounding area ...
Carr, Phillipa
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Mine Closure 2022: Proceedings of the 15th International Conference on Mine Closure (Volume 2)
, 2022 The economically feasible, environmentally benign and socially acceptable closure of mines is one of the greatest challenges facing the mining industry.
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Review of mine closure planning, processes, and a post-closure strategy at Tshikondeni coal mine
Journal of the Southern African Institute of Mining and MetallurgySince the discovery of gold on the Witwatersrand in 1886, mining has been at the centre of South Africa's development. Although mining continues to contribute significantly to the country's economy, it is a temporary land-use activity, and mine closure is inevitable.
N.D. Nxumalo, T. Field
openaire +2 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A new approach to reclamation assessment for mine closure
, 2016 Reclamation assessments on mine sites, to determine equivalent land capability and to meet the regulatory requirements, are often reliant on large amounts of data collected throughout the growing season and often over several years.
Trace Associates Inc. +2 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Computer visual simulations and surface mine closure : three case studies
, 1996 Computer visual simulations are used to portray proposed landscape changes with true color and photo-realistic quality. This technical paper presents three case studies of surface mining operations where computer visual simulations were used in the ...
Ellsworth, John C.
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