Results 101 to 110 of about 10,558 (304)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Closure of the Colomac Mine : a First Nations - mine owner collaboration
, 2006 The reclamation of mines is an important issue for Aboriginal peoples in Canada who have mines in their traditional territories. Mine owners and operators have a responsibility to engage those First Nation communities affected by these projects in ...
Pearse, Anthony Dalton, 1946-
core
FireMethane explosions often occur during the closure process of mine fire zones, during which the concentration of combustible gases such as monoxide and ethylene produced by coal combustion dynamically changes, which changes the risk of methane explosion ...
Dong Ma +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Closure of the Woodhull Mine Chester, New Jersey
, 2004 There are numerous abandoned iron mines that dot the landscape within the Highlands of Morris and Passaic Counties in northeastern New Jersey. In recent years, as development has continued to expand in rural communities in New Jersey, these abandoned ...
McWhorter, James G.
core
Study on the prevention system of rockburst for the entire life cycle of underground coal mines
矿业科学学报The existing prevention and control of rockbursts in mining mainly focus on the production phase, making it challenging to fundamentally curb rockburst disasters.
OUYANG Zhenhua +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Meitan kexue jishuThe closed coal mine water is mostly characterized by high iron. After mine closure and flooding, residual iron-prone devices and iron-bearing minerals form a “dual-source” iron pollution system in mine water, contributing to the release of iron in ...
Lai ZHOU +4 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source