Results 41 to 50 of about 6,946 (259)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Financial guarantee for mine closure [PDF]

Rem: Revista Escola de Minas, 2003
This paper deals with the determination of the amount of a closure guarantee, the most common financial instruments available to the mining companies to satisfy the regulatory agencies' current and anticipated requirements, characteristics, advantages and disadvantages pertaining to these instruments as well as the problems faced by mining companies ...
Lima, Hernani Mota de, Costa, Flávio Luiz da, Peixoto, Robson, Caldeira, Valdecy   +3 more
openaire   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Analysis of the prediction and evolution process of waterfilling in closed coal mine goaf

Meitan xuebao
After coal mine closure, the groundwater level recovers, while the water accumulation process in goaf areas has rarely been studied. Taking Xuzhou Sanhejian closed coal mine as an example. Based on mine closure reports and borehole data, combined with 3D
Yanqing DING, Renhao PANG, Jing QIAN, Lihong DUAN, Taisen CHEN   +4 more
doaj   +1 more source

Sustainability of post-mining land use and ecotourism

Jurnal Perspektif Pembiayaan dan Pembangunan Daerah, 2018
The mining sector can contribute to the state in the form of foreign exchange and state in the form of foreign exchange and funding sources such as royalties, taxes, the expansion of employment and physical development, on the other hand, led to some ...
Herdis Herdiansyah, Marikha Ulfah Utami, Joko Tri Haryanto   +2 more
doaj   +1 more source

Mine closure – misplaced planning priorities [PDF]

Proceedings of the International Conference on Mine Closure, 2013
Mines, unlike many other industrial activities, pass through distinct life-cycle phases from exploration and prefeasibility through operations to closure and rehabilitation. Closure assumptions have become an integral part of the planning for closure process.
Daniel Limpitlaw, Paul Mitchell
openaire   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Potential socio-economic consequences of mine closure

The Journal for Transdisciplinary Research in Southern Africa, 2018
Background: Mine closures generally reveal negligence on the part of mining houses, not only in terms of the environment, but also the surrounding mining communities.
Marietjie Ackermann, Doret Botha, Gerrit van der Waldt   +2 more
doaj   +1 more source