Results 61 to 70 of about 10,558 (304)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

"What does Closure even mean?" at Century Mine: Multiple companies, mine closure trajectories and disputation

Journal of Political Ecology
During the peak of its operation, Century mine, in Australia's western Queensland, was the third largest lead, zinc and silver mine in the world. The mine has had a turbulent history.
Alec Doomadgee, Sarah Elizabeth Holcombe
doaj   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mine Closure and the Aboriginal Estate

, 2019
Numerous large mines located on Australia’s Aboriginal estate1 are in the process of ceasing production or will do so in the coming decade. Mine closure raises issues of enormous environmental, cultural, social and environmental signifi­cance for ...
O'Faircheallaigh, Ciaran, Rebecca, Lawrence   +1 more
core  

Final mine void forms and future land and water uses: Researching the community perspective.

, 2022
For over a century, the Latrobe Valley coal mines have fed local power stations to generate energy supporting Victoria’s economic development. In providing employment and community networks, these mines and power stations have defined a shared identity ...
Baumagartl, Thomas, Morgan, Damian, Reeves, Jess, Reimers, Vaughan, Green, Monica   +4 more
core  

Below Water Table Mining, Pit Lake Formation, and Management Considerations for the Pilbara Mining Region of Western Australia

Mining
Located in northern Western Australia, the Pilbara is the highest productivity region for iron ore and other metal mining in Australia. As elsewhere, mine closure guidelines typically require post-closure landforms to be safe, stable, non-polluting and ...
Cherie D. McCullough
doaj   +1 more source

Comparison of closure measurements with finite element model results in an underground coal mine in central Utah

International Journal of Mining Science and Technology, 2019
Quantitative analysis of mine-wide subsidence at the kilometer scale and details of stress distribution about an advancing longwall face are estimated using an adaptation of the finite element method. The method is well suited to the tasks at hand.
William G. Pariseau, Michael K. McCarter, Jessica M. Wempen   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Radon Concentrations in Dwellings in the Mining Area-Are There Observed Effects of the Coal Mine Closure? [PDF]

Int J Environ Res Public Health, 2022
Wysocka M, Nowak S, Chałupnik S, Bonczyk M.   +3 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source