Results 61 to 70 of about 10,586 (304)
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Closure of the Sullivan Mine tailings facility [PDF]
This paper reviews the geotechnical and hydrological closure activities undertaken at the tailings facilities of this historic mine. The selection of the appropriate design criteria was based on an assessment of the potential consequence of failure ...
Newcombe, Bob +3 more
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Sustainability of post-mining land use and ecotourism
The mining sector can contribute to the state in the form of foreign exchange and state in the form of foreign exchange and funding sources such as royalties, taxes, the expansion of employment and physical development, on the other hand, led to some ...
Herdis Herdiansyah +2 more
doaj +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Contaminated site legislation and mine closure [PDF]
Environmental protection and restoration during mine closure has for many years been regulated under the Mines Act. The potential currently exists for mine closure to trigger the investigation and remediation requirements of the Contaminated Sites ...
Sandstrom, N., Wilson, Cathy A.
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Self-Determination in mine site transitions and mine closure governance across Indigenous nations
This introductory article provides a synthesis of and a conceptual framing for, the five contributing articles in the Special Section "Self-determination in mine closure and mine site transition across nations".
Arn Keeling +2 more
doaj +2 more sources
Potential socio-economic consequences of mine closure
Background: Mine closures generally reveal negligence on the part of mining houses, not only in terms of the environment, but also the surrounding mining communities.
Marietjie Ackermann +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
SNIP Mine : seven years after closure [PDF]
Closure of the Snip Mine was successfully completed in 1999. Portals into the lower underground workings were sealed with water tight plugs while the upper mine openings were sealed with plugs designed to minimize airflow into the mine.
Sibbick, S. J., MacGillivray, Randy
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