Results 121 to 130 of about 98,174 (313)

The Potential for Developing Mine Cavity Water for Water Supplies: Institutional and Water Quality Issues

, 2014
Many communities in the coalfield counties of southwest Virginia lack adequate and safe water supplies. The ability to develop affordable local water sources by using small water treatment plants is an attractive option to a small community and the local
Reaves, Dixie Watts, Younos, Tamim M., Wright, Benjamen A.   +2 more
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Sulfate removal from acid mine water from the deepest active European mine by precipitation and various electrocoagulation configurations

, 2018
Sulfate removal from mine or process water is a key issue in the mining industry. In this paper, precipitation with lime (calcium oxide) was integrated with electrocoagulation for sulfate removal from Pyhäsalmi/Finland mine water.
Sillanpaa, Mika, Wolkersdorfer, Christian, Nariyan, Elham   +2 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Mine water : a resource for transportation of ores from underground mines

, 1985
In underground mining, a hydraulic hoisting system can increase the hoisting capacity without necessitating the sinking of new shafts. There is generally a considerable inflow of groundwater which has to be pumped out.
Sellgren, Anders,
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Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Characterising the acid mine drainage potential of fine coal wastes

, 2013
Includes bibliographical references.Acid mine drainage (AMD) is one of the major environmental challenges facing the South African mining sector. Acid mine drainage has received significant public attention in recent years.
Kotelo, Lerato Olga
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Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bioremediation of Heavy Metal-Contaminated Solution and Aged Refuse by Microbially Induced Calcium Carbonate Precipitation: Further Insights into Sporosarcina pasteurii

Microorganisms
Recently, the ability of microbial-induced calcium carbonate precipitation (MICP) to remediate heavy metals has been widely explored. Sporosarcina pasteurii was selected to remediate heavy metal-contaminated solution and aged refuse, exploring the ...
Dingxiang Zhuang, Weiheng Yao, Yan Guo, Zhengzheng Chen, Herong Gui, Yanyang Zhao   +5 more
doaj   +1 more source

Properties of alkaline materials for injection into weathered mine waste piles : methods and initial pilot trials

, 2011
Several alkaline materials were studied with regards to their ability to form stable suspensions withwater. Gravitational injection of alkaline materials were performed into weathered mine waste in two differentpilot scales (25 L and 1 000 L). When water
Larsson, Erik,, Karlsson, Stefan,, Sartz, Lotta,, Bäckström, Mattias,   +3 more
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