Results 101 to 110 of about 98,174 (313)

Biodiversity benefits of coal mine water remediation schemes for bird life

open access: yes, 2021
Lagoons and reedbeds are established components of mine water treatment systems for iron-rich coal mine drainage. This study coupled modified British Trust for Ornithology (BTO) Breeding Bird Survey monitoring with habitat survey to assess the presence ...
Hull, Susan L   +4 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Mine water management in variable climate regimes

open access: yes, 2012
Recent extreme rainfall events in Queensland have tested both strategic and operational water management practices, infrastructure and regulation of mine water discharge.
Robbins, Sarah, Vink, Sue
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

An assessment of the quantum for financial provision of mine closures: a Monte Carlo approach.

open access: yes, 2012
Includes abstract.Includes bibliographical references.Poor mine closure policy threatens both society and the environment. Some of the more prominent threats that have manifested are acid mine drainage, slimes dams and toxic dust from dumps.
Hewitson, Shaun B
core  

Evaluation of Amendments to Control Phosphorus Losses in Runoff from Dairy-Soiled Water

open access: yes, 2011
peer-reviewedAmendments with the potential to reduce phosphorus (P) losses from agricultural grassland arising from the land application of dairy-soiled water (DSW) were investigated.
Healy, Mark Gerard   +6 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Fracture propagation and pore pressure evolution characteristics induced by hydraulic and pneumatic fracturing of coal

open access: yesScientific Reports
A two-dimensional unsteady seepage model for coal using a finite element program is developed, and the temporal variations of key factors such as water pressure and hydraulic gradient are analyzed in this paper. Additionally, the triaxial rock mechanical
Cao Zhengzheng   +8 more
doaj   +1 more source

Impact of the Casargiu mine drainage on the Mediterranean Sea

open access: yes, 2009
In Sardinia (Italy), Pb-Zn vein ores hosted in Palaeozoic silicate-dominant rocks of the Arburese mining district have been exploited in a system of overlapping galleries for a depth of 600 m below ground level.
CIDU, ROSA, FRAU, FRANCO
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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