Results 41 to 50 of about 2,538,610 (251)

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

Advanced Healthcare Materials, EarlyView.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu, Mahboobeh Mahmoodi, Ehsanul Hoque Apu, Fahimeh Shahabipour, Sibel Emir Diltemiz, Sanjib Saha, Halima Alem, Nureddin Ashammakhi   +7 more
wiley   +1 more source

Effects of osteoporosis and drugs on bone biomechanics. [PDF]

, 1996
PhD16 New Zealand White (NZW) rabbits were ovariectomised (OVX) and 20 left intact as age-matched controls. 4 controls were killed at time 0, then 4 from each group at 1,3,6 and 12 months post-OVX. Serum oestradiol and body weight were recorded.
Bagnall, Anne-Marie
core   +4 more sources

Polymorphisms in genes involved in the NF-κB signalling pathway are associated with bone mineral density, geometry and turnover in men [PDF]

, 2011
<p><b>Introduction:</b> In this study, we aimed to investigate the association between single nucleotide polymorphisms (SNPs) within two genes involved in the NF-kappa B cascade (GPR177 and MAP3K14) and bone mineral density (BMD ...
Wu, Frederick C., O'Neill Terence W., Wu Frederick C., Pendleton Neil, Casanueva, Felipe F., Judith E. Adams, Giwercman, Aleksander, Vanderschueren, Dirk, Holliday, Kate L., Frederick C Wu, Boonen, Steven, Thang S Han, Bartfai, G., Gyorgy Bartfai, Giwercman Aleksander, Ilpo T Huhtaniemi, Terence W. O'Neill, Punab Margus, Adams, J.E., null null, Pendleton, Neil, Pye Stephen R., Kate L. Holliday, Boonen, S., Han, T.S., Michael E. Lean, Holliday, K.L., Stephen R Pye, Huhtaniemi, Ilpo T., Lean, M.E., Dirk Vanderschueren, Adams, Judith E., Margus Punab, Borghs Herman, Felipe F. Casanueva, Judith E Adams, Lean Michael E., Wu, F.C., Herman Borghs, Kula, K., Forti, Gianni, Punab, Margus, Lean, Michael E., Finn, Joseph D., EMAS Study Group, O'Neill, T.W., Finn, J.D., Borghs, Herman, Kula Krzysztof, Joseph D Finn, Thomson, W., Delnaz Roshandel, Huhtaniemi, I.T., Stephen R. Pye, Terence W O'Neill, Giwercman, A., Holliday Kate L., Punab, M., Ward, Kate A., Neil Pendleton, Pye, Stephen R., Casanueva, F.F., Roshandel, Delnaz, Forti Gianni, Kula, Krzysztof, Casanueva Felipe F., Krzysztof Kula, O'Neill, Terence W., Borghs, H., Thang S. Han, Frederick C. Wu, Boonen Steven, Huhtaniemi Ilpo T., Casanueva Freijo, Felipe, Vanderschueren, D., Pendleton, N., Vanderschueren Dirk, Ward, K.A., Forti, G., Han, Thang S., Kate A Ward, Pye, S.R., Ward Kate A., Aleksander Giwercman, Han Thang S., Finn Joseph D., Gianni Forti, Steven Boonen, Bartfai, Gyorgy, Roshandel, D., Adams Judith E., Kate L Holliday, Kate A. Ward, Thomson Wendy, Bartfai Gyorgy, Michael E Lean, Wendy Thomson, Ilpo T. Huhtaniemi, Thomson, Wendy, Joseph D. Finn, Felipe F Casanueva, Roshandel Delnaz   +101 more
core   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The frequency of bone fractures among patients with chronic kidney disease not on dialysis: two-year follow-up

Romanian Journal of Internal Medicine, 2017
Introduction. Renal osteodystrophy is a severe complication of chronic kidney disease (CKD) that increases morbidity and mortality in these patients. Mineral and bone disorder starts early in CKD and affects the incidence of bone fractures.
Figurek Andreja, Vlatkovic Vlastimir, Vojvodic Dragan, Gasic Branislav, Grujicic Milorad   +4 more
doaj   +1 more source

The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men [PDF]

, 2011
<p><b>Purpose:</b> Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor alpha gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMD(a)) of the hip and lumbar ...
Lean, Michael E. J., Holliday Kate L., Gielen, Evelien, Ward, Kate A., Gielen Evelien, O'Neill Terence W., Pendleton Neil, Judith E. Adams, Neil Pendleton, Giwercman, Aleksander, Pye, Stephen R., Vanderschueren, Dirk, Holliday, Kate L., Boonen, Steven, Forti Gianni, Labrie Fernand, Kula, Krzysztof, Thang S Han, Krzysztof Kula, Lean Michael E. J., O'Neill, Terence W., Gyorgy Bartfai, Thang S. Han, Boonen Steven, Huhtaniemi Ilpo T., Michael E. J. Lean, Casanueva Freijo, Felipe, Giwercman Aleksander, Ilpo T Huhtaniemi, Terence W. O'Neill, Labrie, Fernand, Punab Margus, Giwercman, Aleksander,, Vanderschueren Dirk, null null, Wu, Frederick C.W., Han, Thang S., Wu Frederick C. W., Wu, Frederick C. W., Pendleton, Neil, Lund University., Pye Stephen R., Kate A Ward, Kate L. Holliday, Wu, Frederick C W, Ward Kate A., Lean, Michael E.J., Stephen R Pye, Michael E J Lean, Huhtaniemi, Ilpo T., Lean, Michael E J, Aleksander Giwercman, Han Thang S., Finn Joseph D., Dirk Vanderschueren, Gianni Forti, Adams, Judith E., Lean, M.E.J., Margus Punab, Borghs Herman, Judith E Adams, Felipe Casanueva, Steven Boonen, Herman Borghs, Evelien Gielen, Bartfai, Gyorgy, Forti, Gianni, Punab, Margus, Fernand Labrie, Frederick C. W. Wu, Finn, Joseph D., Adams Judith E., Casanueva, Felipe, Kate L Holliday, Kate A. Ward, Borghs, Herman, Kula Krzysztof, Joseph D Finn, Thomson Wendy, Casanueva Felipe, Bartfai Gyorgy, Wendy Thomson, Ilpo T. Huhtaniemi, Thomson, Wendy, Frederick C W Wu, Joseph D. Finn, Stephen R. Pye, Terence W O'Neill, EMAS study group   +88 more
core   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Respiratory failure: A rare complication of chronic kidney disease mineral and bone disorder

, 2019
Background: Disordered metabolism of bone and minerals is a problem frequently encountered in patients with chronic kidney disease. Early biochemical changes include altered calcium and phosphate balance, while advanced disease produces reduced bone ...
Yaxley, J, Scott, T
core   +1 more source