Results 61 to 70 of about 2,538,610 (251)

Relation of Musculoskeletal Strength and Function to Postural Stability in Ambulatory Adults With Cerebral Palsy

Archives of Rehabilitation Research and Clinical Translation, 2020
Objective: To understand the relation of musculoskeletal strength and function to postural stability in ambulatory adults with cerebral palsy (CP) who have already developed muscle atrophy and osteoporosis.
Areum K. Jensen, PhD, Cory E. Low, BS, Pooja Pal, BS, Tiffany N. Raczynski, BS   +3 more
doaj   +1 more source

Bone volume, mineral density, and fracture risk after kidney transplantation.

PLoS ONE, 2022
BackgroundDisordered mineral metabolism reverses incompletely after kidney transplantation in numerous patients. Post-transplantation bone disease is a combination of pre-existing chronic kidney disease and mineral disorder and often evolving ...
Satu Keronen, Leena Martola, Patrik Finne, Inari S Burton, Xiaoyu F Tong, Heikki Kröger, Eero Honkanen   +6 more
doaj   +1 more source

Prediction of risk of fracture in the tibia due to altered bone mineral density distribution resulting from disuse: a finite element study [PDF]

, 2014
The disuse-related bone loss that results from immobilisation following injury shares characteristics with osteoporosis in post-menopausal women and the aged, with decreases in bone mineral density leading to weakening of the bone and increased risk of ...
Allan, David B, Gislason, Magnus K., Coupaud, Sylvie, Allan, David B., Gislason, Magnus, Sasagawa, Keisuke, Tanabe, Yuji, Tanner, K. Elizabeth, Purcell, Mariel   +8 more
core   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Osteoblast specific connexin43 (Cx43) gene deletion in mice leads to reduced bone mass and osteoblast dysfunction.

, 2002
Washington Univ, Div Bone & Mineral Dis, St Louis, MO 63130 USAUNIFESP, Div Rheumatol, Sao Paulo, BrazilUNIFESP, Div Rheumatol, Sao Paulo, BrazilWeb of ...
Castro, C., Sheikh, S., Szejnfeld, Vera Lucia [UNIFESP], Halstead, L., Civitelli, R.   +4 more
core   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

In Situ Programmable Modulation of Hydrogel Stiffness for Stage‐Adaptive Bone Regeneration

Advanced Science, EarlyView.
Near‐infrared (NIR) irradiation triggers Ca2+ release from thermoresponsive nanocarriers, enabling in situ stiffening of an adaptive hydrogel from a soft to a stiff state, thereby sequentially supporting mesenchymal stromal cell stemness and osteogenic differentiation for stage‐adaptive bone regeneration.
Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang   +5 more
wiley   +1 more source

Cardiovascular Risk and Mineral Bone Disorder in Patients with Chronic Kidney Disease

Kidney & Blood Pressure Research, 2013
The term chronic kidney disease-mineral bone disorder has been coined recently to highlight that the disturbed mineral and bone metabolism is a major contributor to vascular calcification and finally cardiovascular disease. This syndrome is characterized
Hagen Staude, Susann Jeske, Karin Schmitz, Gert Warncke, Dagmar-Christiane Fischer   +4 more
doaj   +1 more source

Misdiagnosis of osteoporosis based on a single bone mineral density measurement

, 2010
A bone mineral density (BMD) T-score at or below −2.5 is considered to be osteoporotic However, the uncertainty of BMD measurement can result in a false positive or a false negative diagnosis.
Nguyen, Nguyen D., Frost, Steven A. (R12308), Nguyen, Tuan V., Eisman, John A.   +3 more
core  

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source