ABSTRACT Aims Guideline‐directed medical therapy (GDMT) implementation in heart failure with reduced ejection fraction (HFrEF) remains suboptimal. A computable algorithm was developed to generate a medication optimization score (MOS) and provide guideline‐based recommendations.
Mohamed S. Ali +5 more
wiley +1 more source
Nonsteroidal Versus Steroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Real-World Evidence From a Multicenter Cohort Study. [PDF]
Wu JY, Tseng KJ, Lin YM.
europepmc +1 more source
Spironolactone inhibits the activity of the Na+/H+ exchanger in the aorta of mineralocorticoid-induced hypertensive rats [PDF]
Juan Carreno +9 more
openalex +1 more source
Urinary Peptidomic Profiling In Post‐Acute Sequelae of SARS‐CoV‐2 Infection: A Case‐Control Study
ABSTRACT Post‐acute sequelae of severe acute respiratory syndrome coronavirus 2‐infection (PASC) is challenging to diagnose and treat, and its molecular pathophysiology remains unclear. Urinary peptidomics can provide valuable information on urine peptides that may enable improved and specified PASC diagnosis.
Dilara Gülmez +20 more
wiley +1 more source
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley +1 more source
Mineralocorticoid receptor antagonists modulate ST2 signaling pathway in chronic heart failure [PDF]
M. Lopez +9 more
openalex +1 more source
Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest. [PDF]
Danesh S +18 more
europepmc +1 more source
Three‐quarters of patients who underwent ICD/CRT‐D implantation for secondary prevention received appropriate ICD therapy and survived at least 1 year thereafter. In contrast, patients aged 70 or older and those with a history of ventricular fibrillation (VF) were less likely to benefit from secondary prevention with an ICD.
Rie Akagawa +9 more
wiley +1 more source
Data for "The glucocorticoid receptor potentiates aldosterone-induced transcription by the mineralocorticoid receptor" [PDF]
Thomas A. Johnson +9 more
openalex +1 more source

