Results 281 to 290 of about 76,021 (334)

Monogenic mineralocorticoid hypertension

Best Practice & Research Clinical Endocrinology & Metabolism, 2006
Monogenic mutations leading to excessive activation of the mineralocorticoid pathway result, almost always, in suppressed renin and hypertension in adult life and sometimes in hypokalaemia and alkalosis, which can be severe. In most of these syndromes, precise molecular changes in specific steroidogenic or effector genes have been identified ...
Stowasser, Michael, Gordon, Richard D.
openaire   +3 more sources

Mineralocorticoid and Apparent Mineralocorticoid Syndromes of Secondary Hypertension

Advances in Chronic Kidney Disease, 2015
The mineralocorticoid aldosterone is a key hormone in the regulation of plasma volume and blood pressure in man. Excessive levels of this mineralocorticoid have been shown to mediate metabolic disorders and end-organ damage more than what can be attributed to its effects on blood pressure alone.
Sivakumar Ardhanari, Rohini Kannuswamy, Kunal Chaudhary, Warren Lockette, Adam Whaley-Connell   +4 more
openaire   +2 more sources

Mineralocorticoid Receptor Antagonists

2019
Two mineralocorticoid receptor antagonists, spironolactone and eplerenone, are currently approved by the FDA. Several non-steroid based ligands are in clinical trials for indications including heart failure, hypertension and diabetic kidney disease, and even more structurally distinct chemical series are reported in the literature with preclinical data
Anneli, Nordqvist, Kenneth L, Granberg
openaire   +2 more sources

Adipocyte Mineralocorticoid Receptor

2019
Mineralocorticoid receptor (MR) has been recently identified in adipose tissue, where its excessive activation contributes to several metabolic derangements often observed in obesity and metabolic syndrome. Recent findings support the existence of a bidirectional cross-talk between adipose tissue and adrenal glands, contributing to obesity-related ...
Infante M., Armani A., Marzolla V., Fabbri A., Caprio M.   +4 more
openaire   +4 more sources

Investigating mineralocorticoid hypertension

Journal of Hypertension, 2003
About 3% of our hypertensive patients have high blood pressure induced by corticosteroids. Muscle weakness, tiredness, polyuria and polydipsia may indicate hypokalaemia. Hypokalaemic hypertension in the presence of a low plasma renin activity is the typical finding of corticosteroid hypertension.
openaire   +2 more sources

The role of mineralocorticoid receptor activation in kidney inflammation and fibrosis

Kidney International Supplements, 2022
James M Luther
exaly  

Mineralocorticoid hypertension

The Lancet, 1994
openaire   +3 more sources

Mineralocorticoid Mechanisms

Hormone Research in Paediatrics, 2003
openaire   +2 more sources

Mineralocorticoids and Mineralocorticoid Excess Syndromes

2004
John M.C. Connell, Marie Freel
openaire   +1 more source

Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone

Proceedings of the National Academy of Sciences of the United States of America, 2005
Henk Karst, Günther Schütz
exaly