A comprehensive review of cancer‐induced cardiac wasting
British Journal of Pharmacology, EarlyView.Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena +5 more
wiley +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Background Primary aldosteronism (PA) has been linked with reduced health‐related quality of life (QoL) and increased prevalence of anxiety and depression. While most studies compared patients with PA to healthy subjects, this study focused on comparison with hypertensive patients without PA to identify PA‐specific effects.
Sybille Fuld +15 more
wiley +1 more source
Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss. [PDF]
Int J Mol Sci, 2023 Barnes CC, Yee KT, Vetter DE.
europepmc +1 more source
Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies
Clinical Endocrinology, EarlyView.ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley +1 more source
Identification of Mineralocorticoid Receptors, Aldosterone, and Its Processing Enzyme CYP11B2 on Parasympathetic and Sympathetic Neurons in Rat Intracardiac Ganglia. [PDF]
Front Neuroanat, 2021 Dehe L +6 more
europepmc +1 more source
Non-genomic actions of aldosterone: From receptors and signals to membrane targets. [PDF]
, 2011 In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na(+) channel, in combination with important signalling intermediates such as serum and ...
Dooley, Ruth +2 more
core +1 more source
Clinical Obesity, Volume 15, Issue 2, April 2025.Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton +4 more
wiley +1 more source
Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. [PDF]
Cell Rep, 2021 Hartmann J +17 more
europepmc +1 more source
Brain Proteomic Responses to Glucocorticoids and Their Relationship With Transcriptome: A Systematic Meta-Analysis. [PDF]
FASEB JAn overlap between proteomic and transcriptomic findings in experiments testing brain responses to glucocorticoids. A shows that 455 proteins responsive to glucocorticoids were not confirmed at the transcriptomic level while 4 proteins were matched with significant differences in mRNA in all 8 datasets derived from transcriptomic experiments.
Juszczak GR.
europepmc +2 more sources
Effect of spironolactone on pain responses in mice [PDF]
, 2010 The effects of spironolactone, a non-selective aldosterone antagonist, were examined on thermally-induced pain using the hot-plate and tail-flick tests, on hemogenic pain induced by intraplantar capsaicin, on electrically-induced pain, on visceral ...
Abdel-Salam, Omar M.E. +2 more
core