Results 1 to 10 of about 8,685 (160)
Ac-SDKP and eplerenone confer additive cardioprotection against angiotensin II-induced cardiac injury in C57BL/6J mice [PDF]
Journal of Molecular and Cellular Cardiology PlusEplerenone, a mineralocorticoid receptor antagonist, is an anti-hypertensive and cardioprotective drug. We showed that N-Acetyl-Seryl-Aspartyl-Proline (Ac-SDKP) exerts beneficial effects on the heart.
Suhail Hamid +8 more
doaj +2 more sources
Eplerenone ethanol solvate [PDF]
Acta Crystallographica Section E, 2008 Eplerenone [systematic name: 7α-(methoxycarbonyl)-3-oxo-9α,11-epoxy-17α-pregn-4-ene-21,17-carbolactone], an aldosterone receptor antagonist, crystallizes from ethanol as a monosolvate, C24H30O6·C2H6O.
Duan-Jun Xu +4 more
doaj +3 more sources
Chemical stability study of diuretics in a concomitant simple suspension with magnesium oxide [PDF]
Journal of Pharmaceutical Health Care and SciencesBackground A simple suspension method has been widely used in Japan, however, chemical interactions among drugs in co-suspensions have not been fully clarified.
Ginjiro Kato +5 more
doaj +2 more sources
Nature Reviews Drug Discovery, 2003 Data from animal studies and clinical trials indicate that aldosterone causes cardiovascular and renal injury through mineralocorticoid receptor–dependent mechanisms. However, although aldosterone receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific ...
Ruth, Brown +2 more
openaire +4 more sources
A Prospective Study of Eplerenone in the Treatment of Patients with Glomerulonephritis
Biomedicines, 2023 Background: High aldosterone levels contribute to kidney disease progression, while spironolactone in combination with ACEi or ARBs can potentially reduce proteinuria and ameliorate kidney function deterioration.
Marios Papasotiriou +6 more
doaj +1 more source
Real-world practice patterns of eplerenone use for central serous chorioretinopathy
International Journal of Retina and Vitreous, 2023 Purpose To report eplerenone use by retina specialists worldwide for central serous chorioretinopathy (CSCR). Methods A self-reporting questionnaire was distributed to retina specialists worldwide to gather clinicians’ perspectives on CSCR cases treated,
Ramesh Venkatesh +10 more
doaj +1 more source
Bilateral bullous central serous chorioretinopathy treated with PDT and eplerenone
American Journal of Ophthalmology Case Reports, 2022 Purpose: To report a case evaluating PDT and eplerenone therapy in a patient with bilateral bullous central serous chorioretinopathy. Observations: A 30-year-old male was referred for worsening bilateral bullous central serous chorioretinopathy (bCSCR ...
William J. Anderson, Bradley T. Smith
doaj +1 more source
Effect of Eplerenone, a Selective Aldosterone Blocker, on the Development of Diabetic Nephropathy in Type 2 Diabetic Rats [PDF]
Diabetes & Metabolism Journal, 2012 BackgroundAldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system.
Jae Hee Ahn +14 more
doaj +1 more source
Scientific Reports, 2022 To compare the anatomical/functional changes after navigated subthreshold pulse laser (SML) and oral eplerenone therapy for chronic central serous chorioretinopathy (cCSC). A total of 36 eyes of 36 patients suffering from cCSC treated with navigated SML (
Lisa Toto +10 more
doaj +1 more source
Eplerenone for hypertension [PDF]
Cochrane Database of Systematic Reviews, 2011 Eplerenone is an aldosterone receptor blocker that is chemically derived from spironolactone. In Canada, it is indicated for use as adjunctive therapy to reduce mortality for heart failure patients with New York Heart Association (NYHA) class II systolic chronic heart failure and left ventricular systolic dysfunction.
Tina Sc, Tam +7 more
openaire +2 more sources