Results 1 to 10 of about 8,965 (175)

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities: Geriatrics Branch of Chinese Medical Association, Cardiovascular Group of Geriatrics Branch of Chinese Medical Association. [PDF]

Aging Med (Milton)
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Wang X, Zhang C.
europepmc   +2 more sources

Eplerenone Attenuates Hepatic Oxidative Stress and Mitochondrial Dysfunction Following Renal Ischemia-Reperfusion Injury in Rats [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Acute kidney injury (AKI) is frequently complicated by systemic manifestations, including hepatic dysfunction, largely due to ischemia-reperfusion (I/R) injury.
Alireza Barati, Seyed Mohammadmahdi Meybodi, Kimia Moradi, Sana Nouraei, Mohammad Bakhshi, Soheila Montazersaheb, Sepideh Zununi Vahed   +6 more
doaj   +2 more sources

Eplerenone ethanol solvate [PDF]

Acta Crystallographica Section E, 2008
Eplerenone [systematic name: 7α-(methoxycarbonyl)-3-oxo-9α,11-epoxy-17α-pregn-4-ene-21,17-carbolactone], an aldosterone receptor antagonist, crystallizes from ethanol as a monosolvate, C24H30O6·C2H6O.
Duan-Jun Xu, Jing-Jing Nie, Jian-Yong Yuan, Wei-Dong Ye, Qian Yang   +4 more
doaj   +3 more sources

Eplerenone for Central Serous Chorioretinopathy: Is There Still Room for This Treatment? [PDF]

Biomedicines
Background/Objectives: The purpose of this study was to evaluate the efficacy and safety of oral eplerenone in patients with acute and chronic central serous chorioretinopathy (CSCR).
Irini Chatziralli, Chrysa Agapitou, Stamatios Lampsas, Alexandros Chatzirallis, Alexia Risi-Koziona, Rafaela Smarlamaki, Konstantinos Pappelis, George Theodossiadis, Panagiotis Theodossiadis   +8 more
doaj   +2 more sources

Long-term follow-up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half-dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4. [PDF]

Acta Ophthalmol
Abstract Purpose Assessing the 24‐month treatment outcome of half‐dose photodynamic therapy (PDT) or oral eplerenone in chronic central serous chorioretinopathy (cCSC). Methods Multicentre randomized clinical trial included cCSC patients from the SPECTRA trial who were randomized to receive half‐dose PDT or oral eplerenone.
Feenstra HMA, El Mansori I, van Rijssen TJ, Tsonaka R, Diederen RMH, Hoyng CB, Schlingemann RO, Boon CJF, van Dijk EHC.   +8 more
europepmc   +2 more sources

Postoperative Takotsubo Cardiomyopathy in a Young Woman: A Case Report. [PDF]

Clin Case Rep
Timeline of the patient's clinical course. ABSTRACT Takotsubo cardiomyopathy (TCM) can occur in young adults exposed to extreme physical stress, such as surgery, sepsis, and transfusion reactions. Mechanical recovery may precede electrical normalization, with ECG abnormalities persisting despite improved left ventricular ejection fraction (LVEF). Early
Siddiq N, Cheema ZZ, Khan SS, Arshad A, Awan AR, Shah S, Usman M.   +6 more
europepmc   +2 more sources

Chemical stability study of diuretics in a concomitant simple suspension with magnesium oxide [PDF]

Journal of Pharmaceutical Health Care and Sciences
Background A simple suspension method has been widely used in Japan, however, chemical interactions among drugs in co-suspensions have not been fully clarified.
Ginjiro Kato, Hidemichi Mitome, Mayu Terada, Noriaki Hidaka, Mamoru Tanaka, Kazuki Akira   +5 more
doaj   +2 more sources

Eplerenone [PDF]

Nature Reviews Drug Discovery, 2003
Data from animal studies and clinical trials indicate that aldosterone causes cardiovascular and renal injury through mineralocorticoid receptor–dependent mechanisms. However, although aldosterone receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific ...
Ruth, Brown, Jeremy, Quirk, Peter, Kirkpatrick   +2 more
openaire   +4 more sources

A Prospective Study of Eplerenone in the Treatment of Patients with Glomerulonephritis

Biomedicines, 2023
Background: High aldosterone levels contribute to kidney disease progression, while spironolactone in combination with ACEi or ARBs can potentially reduce proteinuria and ameliorate kidney function deterioration.
Marios Papasotiriou, Georgia Andrianna Georgopoulou, Adamantia Mpratsiakou, Theodoros Ntrinias, Georgios Lyras, Dimitrios S. Goumenos, Evangelos Papachristou   +6 more
doaj   +1 more source

Real-world practice patterns of eplerenone use for central serous chorioretinopathy

International Journal of Retina and Vitreous, 2023
Purpose To report eplerenone use by retina specialists worldwide for central serous chorioretinopathy (CSCR). Methods A self-reporting questionnaire was distributed to retina specialists worldwide to gather clinicians’ perspectives on CSCR cases treated,
Ramesh Venkatesh, Vishma Prabhu, Aishwarya Joshi, Rubble Mangla, Rishi Singh, Lihteh Wu, Paolo Lanzetta, Baruch Kuppermann, Francesco Bandello, Francine Behar Cohen, Jay Chhablani   +10 more
doaj   +1 more source