A Prospective Crossover Clinical Trial of Esaxerenone and Eplerenone in Patients with Chronic Heart Failure Complicated by Hypertension [PDF]
LifeEsaxerenone, which blocks aldosterone binding, is approved to treat hypertension but not heart failure. We aimed to understand esaxerenone’s efficacy in treating chronic heart failure.
Akira Sezai +5 more
doaj +3 more sources
A Prospective Study of Eplerenone in the Treatment of Patients with Glomerulonephritis
Biomedicines, 2023 Background: High aldosterone levels contribute to kidney disease progression, while spironolactone in combination with ACEi or ARBs can potentially reduce proteinuria and ameliorate kidney function deterioration.
Marios Papasotiriou +6 more
doaj +2 more sources
Real-world practice patterns of eplerenone use for central serous chorioretinopathy
International Journal of Retina and Vitreous, 2023 Purpose To report eplerenone use by retina specialists worldwide for central serous chorioretinopathy (CSCR). Methods A self-reporting questionnaire was distributed to retina specialists worldwide to gather clinicians’ perspectives on CSCR cases treated,
Ramesh Venkatesh +10 more
doaj +2 more sources
Ac-SDKP and eplerenone confer additive cardioprotection against angiotensin II-induced cardiac injury in C57BL/6J mice [PDF]
Journal of Molecular and Cellular Cardiology PlusEplerenone, a mineralocorticoid receptor antagonist, is an anti-hypertensive and cardioprotective drug. We showed that N-Acetyl-Seryl-Aspartyl-Proline (Ac-SDKP) exerts beneficial effects on the heart.
Suhail Hamid +8 more
doaj +2 more sources
Bilateral bullous central serous chorioretinopathy treated with PDT and eplerenone
American Journal of Ophthalmology Case Reports, 2022 Purpose: To report a case evaluating PDT and eplerenone therapy in a patient with bilateral bullous central serous chorioretinopathy. Observations: A 30-year-old male was referred for worsening bilateral bullous central serous chorioretinopathy (bCSCR ...
William J. Anderson, Bradley T. Smith
doaj +2 more sources
Eplerenone for Central Serous Chorioretinopathy: Is There Still Room for This Treatment? [PDF]
BiomedicinesBackground/Objectives: The purpose of this study was to evaluate the efficacy and safety of oral eplerenone in patients with acute and chronic central serous chorioretinopathy (CSCR).
Irini Chatziralli +8 more
doaj +2 more sources
Eplerenone ethanol solvate [PDF]
Acta Crystallographica Section E, 2008 Eplerenone [systematic name: 7α-(methoxycarbonyl)-3-oxo-9α,11-epoxy-17α-pregn-4-ene-21,17-carbolactone], an aldosterone receptor antagonist, crystallizes from ethanol as a monosolvate, C24H30O6·C2H6O.
Duan-Jun Xu +4 more
doaj +3 more sources
Postpartum administration of eplerenone to mitigate vascular dysfunction in mice following a preeclampsia-like pregnancy [PDF]
Scientific ReportsPreeclampsia is a severe pregnancy complication associated with substantial injury to systemic vasculature, major organs, and the feto-placental unit, with an approximate mortality rate of 76,000 pregnant women and 500,000 babies each year.
Natalie K. Binder +7 more
doaj +2 more sources
Nature Reviews Drug Discovery, 2003 Data from animal studies and clinical trials indicate that aldosterone causes cardiovascular and renal injury through mineralocorticoid receptor–dependent mechanisms. However, although aldosterone receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific ...
Ruth, Brown +2 more
openaire +4 more sources
Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study [PDF]
, 2018 Objective: Aldosterone stimulates cardiac collagen synthesis. Circulating biomarkers of collagen turnover provide a useful tool for the assessment of cardiac remodeling in patients with an acute myocardial infarction (MI).
A Struthers +39 more
core +15 more sources