Results 51 to 60 of about 17,051 (177)

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Analysis of MADS-Box Gene Family Reveals Conservation in Floral Organ ABCDE Model of Moso Bamboo (Phyllostachys edulis)

Frontiers in Plant Science, 2017
Mini chromosome maintenance 1, agamous, deficiens, and serum response factor (MADS)-box genes are transcription factors which play fundamental roles in flower development and regulation of floral organ identity.
Zhanchao Cheng, Wei Ge, Long Li, Dan Hou, Yanjun Ma, Jun Liu, Qingsong Bai, Xueping Li, Shaohua Mu, Jian Gao   +9 more
doaj   +1 more source

Pangenome analysis reveals the genetic mechanism underlying high‐altitude adaptation in Qinghai–Xizang (Tibet) Plateau Rhododendron

Journal of Integrative Plant Biology, EarlyView.
Pan‐genome analysis reveals that high‐altitude Rhododendron species resist alpine cold stress by rapidly sensing and engaging the chilling response pathway and genes that directly and indirectly protect the plant from UV radiation. Heritable genomic features such as long terminal repeats contribute to the adaptive diversification of Rhododendron ...
Haoyang Zhou, Zhongping Xu, Fanhuang Zeng, Haiyu Sang, Zhenhua Liu, Miao Sun, Qiang Fu, Kaige Zhao, Daming Tan, Manzhu Bao, Shuangxia Jin, Xiuqun Liu   +11 more
wiley   +1 more source

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Fine‐root trait variation in temperate trees follows arc‐shape pattern along deep soil profiles

New Phytologist, EarlyView.
Root trait variation along the soil depth profile in four temperate tree species. Summary Roots are plants' interface with the soil, controlling access to water and nutrients. Yet, fine‐root trait variation along deep soil profiles and its functional implications remain poorly understood.
Katrin Pietig, Christoph Leuschner, Heinz Coners, Martyna M. Kotowska   +3 more
wiley   +1 more source

РЕЗУЛЬТАТИ ПОЛЬОВИХ ДОСЛІДЖЕНЬ ДВОДИСКОВИХ СОШНИКІВ ДЛЯ СІВБИ ЗЕРНОВИХ КУЛЬТУР ЗА ТЕХНОЛОГІЄЮ MINI-TILL

Scientific bulletin of the Tavria State Agrotechnological University
Розглянуто питання вдосконалення технологічного процесу сівби зернових культур за умов мінімального обробітку ґрунту. Запропоновано конструкцію дводискового сошника з вирізним диском для використання в зернових сівалок типу СЗ, призначеного для підвищення якості сівби за технологією Minitill. Наведено опис конструкції сошника, який забезпечує ефективне
openaire   +1 more source

Point mutation in zinc sensor causes a threefold zinc level increase in Sorghum bicolor

New Phytologist, EarlyView.
Point mutation in sensor triples zinc levels in Sorghum bicolor.
Feixue Liao, Anko Blaakmeer, Liliana S. Silva, Søren Knudsen, Ana G. L. Assunção   +4 more
wiley   +1 more source

THE FIRST EXPERIENCE OF KIDNEY TRANSPLANTАTION IN THE CLINICAL HOSPITAL OF ALMATY

Вестник трансплантологии и искусственных органов, 2015
Aim: To estimate results of kidney transplantation in city clinical hospital No. 7 of Almaty. Materials and methods. 100 patients who underwent kidney transplantation in our institution were analyzed; males – 54 (54%), females – 46 (46%), aged from 14 ...
B. B. Baimakhanov, Zh. N. Kyzhyrov, M. M. Sakhipov, A. T. Chormanov, T. K. Kuandikov, R. P. Ibragimov, Ch. T. Sadykov, D. A. Issayev   +7 more
doaj   +1 more source

Designed Alleles of ZmRap2.7 Decouple the Trade‐Off Between Early Flowering and Yield Penalty

Plant Biotechnology Journal, EarlyView.
ABSTRACT Flowering time genes often exhibit pleiotropic effects. In particular, early flowering is frequently associated with reduced grain yield due to a shorter growth period. This trade‐off poses a major challenge for developing early‐maturing and high‐yielding varieties, a key breeding objective in modern maize production. Here, we demonstrate that
Shumin Wang, Junjie He, Lufei Zhang, Li Guo, Ruchang Ren, Xu Han, Lishuan Wu, Huayuan Zhang, Dezhi Deng, Xiangyang Guo, Fang Yang, Chenglong Wang, Feng Tian, Yameng Liang   +13 more
wiley   +1 more source