Results 91 to 100 of about 14,380 (242)

Variation in mitochondrial minichromosome composition among Hoplopleura lice (Phthiraptera: Hoplopleuridae) from rats [PDF]

, 2020
Yi-Tian Fu, Yu Nie, De-Yong Duan, Guo‐Hua Liu   +3 more
openalex   +3 more sources

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

npj Breast Cancer, 2021
Resistance to endocrine therapy in estrogen receptor-positive (ER+) breast cancer is a major clinical problem with poorly understood mechanisms. There is an unmet need for prognostic and predictive biomarkers to allow appropriate therapeutic targeting ...
Sanne Løkkegaard, Daniel Elias, Carla L. Alves, Martin V. Bennetzen, Anne-Vibeke Lænkholm, Martin Bak, Morten F. Gjerstorff, Lene E. Johansen, Henriette Vever, Christina Bjerre, Tove Kirkegaard, Bo Nordenskjöld, Tommy Fornander, Olle Stål, Linda S. Lindström, Laura J. Esserman, Anne E. Lykkesfeldt, Jens S. Andersen, Rikke Leth-Larsen, Henrik J. Ditzel   +19 more
doaj   +1 more source

Phosphorylation of Minichromosome Maintenance 3 (MCM3) by Checkpoint Kinase 1 (Chk1) Negatively Regulates DNA Replication and Checkpoint Activation*

Journal of Biological Chemistry, 2015
Background: Chk1 and the MCM complex play important roles in DNA replication and replication checkpoint. Results: Chk1 phosphorylates MCM3. Conclusion: Phosphorylation of MCM3 by Chk1 regulates normal DNA replication and checkpoint.
Xiangzi Han, Franklin Mayca Pozo, Jacob N Wisotsky, Benlian Wang, J. Jacobberger, Youwei Zhang   +5 more
semanticscholar   +1 more source

Mapping the transcriptional landscape of algal resistance to viral infection reveals a core expression program

New Phytologist, Volume 248, Issue 3, Page 1368-1384, November 2025.
Summary Algal blooms and their demise by viruses drive global‐scale ecological processes in the ocean. These blooms form the foundation of marine food webs, regulate microbial communities, and shape biogeochemical cycles. Although algal populations are constantly infected by viruses, resistant subpopulations frequently emerge after the infection.
Talia S. Shaler, Amir Fromm, Daniella Schatz, Shifra Ben‐Dor, Ester Feldmesser, Assaf Vardi   +5 more
wiley   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Prenatal p25-activated Cdk5 induces pituitary tumorigenesis through MCM2 phosphorylation-mediated cell proliferation

Neoplasia: An International Journal for Oncology Research
Aberrant expression of cyclin-dependent kinase 5 (Cdk5) has been reported in pituitary adenomas. However, the role of Cdk5 in the tumorigenesis remains unclear. We show that prenatal p25-activated Cdk5 phosphorylates minichromosome maintenance protein 2 (
Yingwei Huang, Qiqi Wang, Weiwei Zhou, Yawei Jiang, Kai He, Wei Huang, Yating Feng, Hong Wu, Lijuan Liu, Yue Pan, Yihua Huang, Zirui Chen, Wei Li, Yaowei Huang, Guanchuan Lin, Yulong Zhang, Yongyan Ren, Kaibiao Xu, Yanlin Yu, Yuping Peng, Xinghua Pan, Suyue Pan, Hailiang Hu, Yafang Hu   +23 more
doaj   +1 more source

Effects of Differential Commercial Husbandry Conditions on the Tasmanian Atlantic Salmon Egg Transcriptome

Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.
ABSTRACT Maternally inherited transcripts are crucial for the developmental competence of salmon embryos. Due to the wide variety of broodstock conditioning approaches used in commercial aquaculture, there is a need to understand how dynamic commercial environments impact the egg transcriptome and subsequent quality.
Xin Zhan, Mark Adams, Louise Adams, Gianluca Amoroso, Kelli Anderson   +4 more
wiley   +1 more source

Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex

Nucleic Acids Research, 2015
The minichromosome maintenance complex (MCM) represents the replicative DNA helicase both in eukaryotes and archaea. Here, we describe the solution structure of the C-terminal domains of the archaeal MCMs of Sulfolobus solfataricus (Sso) and ...
C. Wiedemann, A. Szambowska, S. Häfner, O. Ohlenschläger, K. Gührs, M. Görlach   +5 more
semanticscholar   +1 more source

Targeting c‐Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple‐negative breast cancer

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
1. Ras inhibition (Salirasib) combined with c‐Myc targeting blocks MCM2‐driven DNA replication, inducing cell‐cycle arrest and apoptosis. 2. Dual inhibition remodels the immunosuppressive TME, polarising macrophages to M1 and enhancing PD‐L1 blockade efficacy. 3.
Xiaojie Liang, Yiqiu Liu, Ye Zhu, Yuhan Zhao, Fan Ye, Fangyan Gao, Yaqin Shi, Xiaoxiang Guan   +7 more
wiley   +1 more source

Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Genome Research, 2015
Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models.
Dimiter Kunnev, Amy Freeland, Maochun Qin, Robert W. Leach, Jianmin Wang, R. Shenoy, S. Pruitt   +6 more
semanticscholar   +1 more source