Results 101 to 110 of about 14,380 (242)
Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets
MedComm, Volume 6, Issue 10, October 2025.Regarding the general picture of heart regeneration therapy, it encompasses exogenous cell therapy, endogenous medications, metabolism, interventions in gene pathways, as well as the therapeutic strategies in the burgeoning interdisciplinary field of medicine and engineering in recent years.
Mingchuan Liu +9 more
wiley +1 more source
PLoS ONE, 2015 The HBV covalently closed circular DNA (cccDNA) is organized as a mini-chromosome in the nuclei of infected hepatocytes by histone and non-histone proteins.
G. A. Palumbo +10 more
semanticscholar +1 more source
Cancer Science, Volume 116, Issue 10, Page 2699-2711, October 2025.We have uncovered a novel mechanism by which HROB modulates cell proliferation in lung adenocarcinoma. Our findings suggest that HROB recruits ZC3HC1 and mediates its de‐phosphorylation at Ser354, which in turn promotes K27‐linked ubiquitination of CCNB1, leading to its proteasomal degradation.
Zhe Zhang +12 more
wiley +1 more source
DNA Induces Conformational Changes in a Recombinant Human Minichromosome Maintenance Complex
Journal of Biological Chemistry, 2015 Background: The human minichromosome maintenance (hMCM) complex is an important component of the DNA replication apparatus. Results: After being produced in Escherichia coli, hMCM has ATPase and DNA helicase activity and undergoes a conformational change
E. Hesketh +6 more
semanticscholar +1 more source
Function of Minichromosome maintenance protein 7 (MCM7) in the Brain in a Rat Experimental Subarachnoid Hemorrhage Model [PDF]
, 2023 GUOJUN WANG +7 more
openalex +1 more source
Contact Dermatitis, Volume 93, Issue 4, Page 316-327, October 2025.The carba mix was studied in a human cell model to better understand human patch reactions to the mix. Our results support that the carba mix can give rise to cocktail effect and that patch testing with separate carba mix sensitisers may thus be more appropriate.
Linda Ljungberg Silic +5 more
wiley +1 more source
cccDNA epigenetic regulator as target for therapeutical vaccine development against hepatitis B
Annals of HepatologyChronic hepatitis B virus infection (CHB) remains a global health concern, with currently available antiviral therapies demonstrating limited effectiveness in preventing hepatocellular carcinoma (HCC) development.
Patricia Gita Naully +4 more
doaj +1 more source
BMC Cancer, 2005 Background Minichromosome maintenance (MCM) proteins are essential for the initiation of DNA replication and have been found to be relevant markers for prognosis in a variety of tumours.
Wild Peter J +7 more
doaj +1 more source
BMC Cancer, 2014 Gliomas are the most common type of all central nervous system tumors. Almost all patients diagnosed with these tumors have a poor prognostic outcome. We aimed to identify novel glioma prognosis-associated candidate genes.
C. Hua, Gang Zhao, Yun-qian Li, L. Bie
semanticscholar +1 more source