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Engineered minichromosomes in plants
Chromosome Research, 2014Platforms for the development of synthetic chromosomes in plants have been produced in several species using telomere mediated chromosomal truncation with the simultaneous inclusion of sites that facilitate further additions to the newly generated minichromosome.
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Minichromosome maintenance proteins in cancer screening
European Journal of Cancer, 2009Early detection of cancer leads to more effective treatment and improved patient survival. Many current cancer screening tests examine cells obtained from the surface of stratified epithelia, such as those of the cervix, urinary bladder, large bowel or airways.
Nicholas, Coleman, Ronald A, Laskey
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The FEBS Journal, 2014
It has been reported that minichromosome maintenance protein‐binding protein (MCM‐BP) functions in the formation of the pre‐replication complex, unloading of minichromosome maintenance (MCM)2–7 from chromatin in late S phase, and formation of the cohesion complex by interacting with MCM3–7 proteins, suggesting that MCM‐BP functions in several different
Shunsuke, Kusunoki, Yukio, Ishimi
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It has been reported that minichromosome maintenance protein‐binding protein (MCM‐BP) functions in the formation of the pre‐replication complex, unloading of minichromosome maintenance (MCM)2–7 from chromatin in late S phase, and formation of the cohesion complex by interacting with MCM3–7 proteins, suggesting that MCM‐BP functions in several different
Shunsuke, Kusunoki, Yukio, Ishimi
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Symmetrical adenovirus minichromosomes have hairpin replication intermediates
Gene, 1992A special class of panhandles (hairpin or foldback structures) arising from the replication of symmetrical adenovirus (Ad) minichromosome dimers and oligomers have been identified by two-dimensional gel electrophoresis. Hairpins provide evidence for replicative intermediates in the pathway for Ad complementary-strand synthesis.
C H, Hu +4 more
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Chapter 11 Yeast Minichromosomes
1991Publisher Summary This chapter discusses the advantages and disadvantages of minichromosomes as an experimental system and reviews some of the questions regarding chromatin structure, which are successfully addressed using yeast minichromosomes. It describes general methods for their isolation, with an analysis of the strengths and weaknesses of each
Sharon Y. Roth, Robert T. Simpson
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Isolation of minichromosomes from yeast cells
1999Publisher Summary This chapter describes the procedure of isolation of minichromosomes from yeast cells. Several methods for the isolation of yeast chromatin in the form of small plasmids have been described, but they suffer from various problems that reflect the difficulty of isolating a small amount of relatively pure minichromosome from the huge ...
J A, Alfieri, D J, Clark
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A nucleosome-free region in SV40 minichromosomes
Nature, 1980Simian virus 40 (SV40) DNA is found in infected cells in the form of a minichromosome1. It possesses a beaded structure composed of cellular histones and supercoiled viral DNA in a molecular complex which is very similar to that of cellular chromatin2–4.
E B, Jakobovits, S, Bratosin, Y, Aloni
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Plant engineered minichromosomes and artificial chromosome platforms
Cytogenetic and Genome Research, 2008The introduction of telomere sequences during transformation of maize will cause chromosomal truncation. This technique has been used to create minichromosomes. With the simultaneous introduction of site specific recombination cassettes, the ability to add additional genes to the newly formed engineered minichromosome becomes possible.
J A, Birchler, W, Yu, F, Han
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Minichromosomes and artificial chromosomes in Arabidopsis
Chromosome Research, 2014Minichromosomes have been extensively used as tools for revealing the functional structures of eukaryotic chromosomes. However, the definition of a minichromosome is still ambiguous. Based on previous reports on various eukaryotes, minichromosomes are defined here to be chromosomes that are smaller than one third the size of the smallest chromosome in ...
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Host controlled plasmid replication: Escherichia coli minichromosomes
Plasmid, 2004Escherichia coli minichromosomes are plasmids replicating exclusively from a cloned copy of oriC, the chromosomal origin of replication. They are therefore subject to the same types of replication control as imposed on the chromosome. Unlike natural plasmid replicons, minichromosomes do not adjust their replication rate to the cellular copy number and ...
Santanu, Dasgupta +1 more
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