Results 21 to 30 of about 14,380 (242)

Molecular functions of MCM8 and MCM9 and their associated pathologies

iScience, 2023
Summary: Minichromosome Maintenance 8 Homologous Recombination Repair Factor (MCM8) and Minichromosome Maintenance 9 Homologous Recombination Repair Factor (MCM9) are recently discovered minichromosome maintenance proteins and are implicated in multiple ...
Noah Cornelis Helderman, Diantha Terlouw, Laia Bonjoch, Mariano Golubicki, Marina Antelo, Hans Morreau, Tom van Wezel, Sergi Castellví-Bel, Yael Goldberg, Maartje Nielsen   +9 more
doaj   +1 more source

Fragmented mitochondrial genomes of seal lice (family Echinophthiriidae) and gorilla louse (family Pthiridae): frequent minichromosomal splits and a host switch of lice between seals

BMC Genomics, 2022
Background The mitochondrial (mt) genomes of 15 species of sucking lice from seven families have been studied to date. These louse species have highly dynamic, fragmented mt genomes that differ in the number of minichromosomes, the gene content, and gene
Yalun Dong, Min Zhao, Renfu Shao
doaj   +1 more source

IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA

Clinical Epigenetics, 2020
Background Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus.
Ying Yuan, Hongfeng Yuan, Guang Yang, H. Yun, Man Zhao, Zixian Liu, Lina Zhao, Y. Geng, Lei Liu, Jiapei Wang, Huihui Zhang, Yufei Wang, Xiao-dong Zhang   +12 more
semanticscholar   +1 more source

Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure. [PDF]

PLoS ONE, 2008
Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subunits.
Alexandra Surcel, Douglas Koshland, Hong Ma, Robert T Simpson   +3 more
doaj   +1 more source

Unwinding 20 Years of the Archaeal Minichromosome Maintenance Helicase

Journal of Bacteriology, 2020
Replicative DNA helicases are essential cellular enzymes that unwind duplex DNA in front of the replication fork during chromosomal DNA replication. Replicative helicases were discovered, beginning in the 1970s, in bacteria, bacteriophages, viruses, and ...
Lori M. Kelman, W. B. O’Dell, Z. Kelman   +2 more
semanticscholar   +1 more source

Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress

G3: Genes, Genomes, Genetics, 2022
Upon replication stress, ssDNA, coated by the ssDNA-binding protein RPA, accumulates and generates a signal to activate the replication stress response. Severe replication stress induced by the loss of minichromosome maintenance helicase subunit Mcm4 in ...
Seong Min Kim, Susan L Forsburg
doaj   +1 more source

Epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection

Biophysics Reports, 2020
Hepatitis B is caused by hepatitis B virus (HBV), and persistent HBV infection is a global public health problem, with 257 million people as HBV chronic carriers.
Zhaoning Wang, Weiwei Wang, Lanfeng Wang
semanticscholar   +1 more source

Minichromosome Maintenance Mobility♦

Journal of Biological Chemistry, 2006

openalex   +2 more sources

KSHV LANA—The Master Regulator of KSHV Latency

Viruses, 2014
Kaposi’s sarcoma associated herpesvirus (KSHV), like other human herpes viruses, establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic phases. The latent phase is characterized by the persistence of viral episomes in
Timsy Uppal, Sagarika Banerjee, Zhiguo Sun, Subhash C. Verma, Erle S. Robertson   +4 more
doaj   +1 more source

Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.

PLoS Pathogens, 2022
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), serving as the viral persistence form and transcription template of HBV infection, hijacks host histone and non-histone proteins to form a minichromosome and utilizes posttranslational ...
Elena S Kim, Jun Zhou, Hu Zhang, Alexander Marchetti, Maarten van de Klundert, Dawei Cai, Xiaoyang Yu, Bidisha Mitra, Yuanjie Liu, Mu Wang, Ulrike Protzer, Haitao Guo   +11 more
doaj   +1 more source