Results 41 to 50 of about 14,380 (242)
Retinoid X Receptor α-Dependent HBV Minichromosome Remodeling and Viral Replication
Annals of Hepatology, 2017 Background and aim. The HBV covalently closed circular DNA (cccDNA) is organized into a minichromosome in the nuclei of infected hepatocytes through interactions with histone and nonhistone proteins.
Yan Zhang +5 more
doaj +1 more source
Engineered plant minichromosomes
The International Journal of Developmental Biology, 2013 Minichromosomes offer an enormous potential for plant breeding and biotechnology, because they may simultaneously transfer and stably express multiple genes. Segregating independently of their host chromosomes, they provide a platform for accelerating plant breeding.
Andreas, Houben +4 more
openaire +3 more sources
Minichromosome maintenance protein in myxofibrosarcoma [PDF]
Modern Pathology, 2003 Histopathological assessment of myxofibrosarcoma may be difficult, especially on the basis of a small core biopsy, which enables only a crude evaluation of grade and prognosis. We have tested the hypothesis that determination of cell cycle state may assist in the diagnostic assessment of myxofibrosarcoma.
Sington, James D. +6 more
openaire +3 more sources
Asian Pacific Journal of Cancer Prevention, 2019 Objective: Minichromosome maintenance complex (MCM) proteins are essential for the process of DNA replication and cell division. This study aimed to evaluate MCM genes expression profiles and MCM2 protein in HPV-associated cervical carcinogenesis ...
G. Kaur +4 more
semanticscholar +1 more source
The Minichromosome Maintenance Replicative Helicase [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is composed of six distinct, but related, subunits MCM(2-7). The relationship between the sequences of the subunits indicates that they are derived from a common ancestor and indeed, present-day archaea possess a homohexameric MCM.
Stephen D, Bell, Michael R, Botchan
openaire +2 more sources
Journal of experimental & clinical cancer research : CR, 2019 Hepatocellular carcinoma (HCC) is the most common tumors in the worldwide, it develops resistance to radiotherapy during treatment, understanding the regulatory mechanisms of radioresistance generation is the urgent need for HCC therapy. qRT-PCR, western
Wei Meng +9 more
semanticscholar +1 more source
Frontiers in Oncology, 2021 BackgroundMinichromosome maintenance (MCM) is known for participating in cell cycle progression, as well as DNA replication. While the diverse expression patterns and prognostic values of MCMs in melanoma still remained unclear.MethodsIn the present ...
Wei Han +8 more
doaj +1 more source
PLoS ONE, 2013 To obtain an overall picture of the repair of DNA single and double strand breaks in a defined region of chromatin in vivo, we studied their repair in a ~170 kb circular minichromosome whose length and topology are analogous to those of the closed loops ...
Slawomir Kumala +4 more
doaj +1 more source
PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA
Cell Death and Disease, 2022 Hepatitis B virus infection remains a major health problem worldwide due to its high risk of liver failure and hepatocellular carcinoma. Covalently closed circular DNA (cccDNA), which is present as an individual minichromosome, serves as the template for
Yao Fan, Yi Liang, Yu Liu, Hui Fan
doaj +1 more source
Plant Physiology, 2019 The nuclear localized PROHIBITIN3 acts as a transcriptional co-regulator that sustains genome integrity and cell proliferation by directly suppressing the expression of MINICHROMOSOME MAINTENANCE 2.
Ruihuan Huang +7 more
semanticscholar +1 more source