Results 51 to 60 of about 14,380 (242)

LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1

Advanced Science, 2022
Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents.
Yang Sun, Yan Teng, Liyuan Wang, Zhaoying Zhang, ChaoJia Chen, Yingchun Wang, Xiaodong Zhang, Peng Xiang, Xiaojia Song, Jinghui Lu, Nailin Li, Lifen Gao, Xiaohong Liang, Yuchen Xia, Zhuanchang Wu, Chunhong Ma   +15 more
doaj   +1 more source

Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena

Microorganisms, 2023
Locus-specific gene amplification and genome-wide endoreplication generate the elevated copy number of ribosomal DNA (rDNA, 9000 C) and non-rDNA (90 C) chromosomes in the developing macronucleus of Tetrahymena thermophila.
Xiangzhou Meng, Hung Quang Dang, Geoffrey M. Kapler   +2 more
doaj   +1 more source

Prognostic significance of minichromosome maintenance mRNA expression in human lung adenocarcinoma

Oncology Report, 2019
The minichromosome maintenance (MCM) gene family plays an essential role in DNA replication and cell cycle progression. However, MCM gene expression has not been well-studied in lung adenocarcinoma (LUAD). In the present study, the expression, prognostic
Shu Li, Zhou Jiang, Yirun Li, Yang Xu
semanticscholar   +1 more source

Ιn vivo imaging of DNA-bound minichromosome maintenance complex in embryonic mouse cortex

STAR Protocols, 2021
Summary: The recruitment of the minichromosome maintenance complex (MCM) on DNA replication origins is a critical process for faithful genome duplication termed licensing.
Maria Mougkogianni, Argyro Kalogeropoulou, Nickolaos Nikiforos Giakoumakis, Zoi Lygerou, Stavros Taraviras   +4 more
doaj   +1 more source

Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma

Journal of Cancer, 2018
Background: The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC).
Xiwen Liao, Xiaoguang Liu, Chengkun Yang, Xiangkun Wang, Ting-dong Yu, Chuangye Han, Ke-tuan Huang, Guangzhi Zhu, Hao Su, Weijuan Qin, Rui Huang, Long Yu, Jianlong Deng, Xianmin Zeng, Xinping Ye, T. Peng   +15 more
semanticscholar   +1 more source

Expression of Minichromosome Maintenance Proteins (MCM) and Cancer Prognosis: A meta-analysis

Journal of Cancer, 2018
Minichromosome maintenance proteins (MCM) played a critical role in replication and cell cycle progression. However, their prognostic roles in cancer remain controversial.
K. Gou, Jing-wei Liu, Xue Feng, Hao Li, Yuan Yuan, Chengzhong Xing   +5 more
semanticscholar   +1 more source

cccDNA Surrogate MC-HBV–Based Screen Identifies Cohesin Complex as a Novel HBV Restriction FactorSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV), existing as a stable minichromosome in the hepatocyte, is responsible for persistent HBV infection.
Zhuanchang Wu, Liyuan Wang, Xin Wang, Yang Sun, Haoran Li, Zhaoying Zhang, Caiyue Ren, Xiaohui Zhang, Shuangjie Li, Jinghui Lu, Leiqi Xu, Xuetian Yue, Yue Hong, Qiang Li, Haizhen Zhu, Yaoqin Gong, Chengjiang Gao, Huili Hu, Lifen Gao, Xiaohong Liang, Chunhong Ma   +20 more
doaj   +1 more source

Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma

OncoTargets and Therapy, 2018
Background Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell
Wei Wu, Xianwei Wang, Changting Shan, Yong Li, Fengzhu Li   +4 more
semanticscholar   +1 more source

Genetic map‐guided genome assembly reveals a virulence‐governing minichromosome in the lentil anthracnose pathogen Colletotrichum lentis

New Phytologist, 2018
Summary Colletotrichum lentis causes anthracnose, which is a serious disease on lentil and can account for up to 70% crop loss. Two pathogenic races, 0 and 1, have been described in the C. lentis population from lentil.
V. Bhadauria, Ron Maclachlan, C. Pozniak, Aurelie Cohen-Skalie, Li Li, J. Halliday, S. Banniza   +6 more
semanticscholar   +1 more source

Mapping of Abutilon Mosaic Geminivirus Minichromosomes [PDF]

Journal of Virology, 2003
ABSTRACTThe single-stranded circular DNA ofAbutilon mosaic geminivirionsis complemented to double-stranded DNA by host proteins after infecting cells. This double-stranded DNA serves as a template for replication as well as transcription and is assembled into host nucleosomes, yielding circular viral minichromosomes.
Marcel, Pilartz, Holger, Jeske
openaire   +2 more sources