Results 71 to 80 of about 14,380 (242)
A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery
Aging Cell, Volume 25, Issue 2, February 2026.This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng +14 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2014 Genetic instability has emerged as an important hallmark of human neoplasia. Although most types of cancers exhibit genetic instability to some extent, in colorectal cancers genetic instability is a distinctive characteristic.
Mauricio Quimbaya +8 more
doaj +1 more source
The minichromosome maintenance complex drives esophageal basal zone hyperplasia
JCI Insight, 2023 Eosinophilic esophagitis (EoE) is a chronic gastrointestinal disorder characterized by food antigen–driven eosinophilic inflammation and hyperproliferation of esophageal mucosa.
Mark Rochman +9 more
doaj +1 more source
, 2021 Genetic engineering is an important method for increasing crop quality and production while lowering labour and resource use in agriculture (Ceccarelli et al., 1992). Traditionally, genetic modification has been accomplished by either Agrobacterium-mediated transformation (Opabode et al., 2006) or direct transformation using a gene gun and particle ...
openaire +1 more source
Journal of Proteome Research, 2016 The extensive identification of protein-protein interactions under different conditions is an important challenge to understand the cellular functions of proteins.
Marie‐Line Dubois +3 more
semanticscholar +1 more source
Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal +3 more
wiley +1 more source
Subunit Structure of Simian‐Virus‐40 Minichromosome [PDF]
European Journal of Biochemistry, 1976 Electron microscopic evidence indicates that Simian virus 40 (SV40) minichromosomes extracted from infected cells consist of 20 ± 2 nucleosomes, each containing 190‐200 base pairs of DNA. About 50% of the nucleosomes are not close together, but connected by segments of DNA of irregular lengths which correspond to about 15% of the viral genome ...
M, Bellard +3 more
openaire +2 more sources
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis
Glia, Volume 73, Issue 12, Page 2407-2426, December 2025.Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf +3 more
wiley +1 more source
Journal of Cytology, 2017 Aims: We aimed to investigate the immunocytoexpression profiles of a novel assay ProEx C for topoisomerase II alpha (TOP2A) and minichromosome maintenance protein 2 (MCM2) in abnormal interpreted smears.
Zeynep Tosuner +5 more
doaj +1 more source
FEBS Open Bio, 2023 Lung cancer is the most common cause of cancer‐related death worldwide, accounting for 1.8 million deaths annually. Analysis of The Cancer Genome Atlas data showed that all members of the minichromosome maintenance (MCM) family (hexamers involved in DNA ...
Kengo Tanigawa +9 more
doaj +1 more source