Results 81 to 90 of about 14,380 (242)
The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans
Biology, 2023 Understanding human DNA replication through the study of yeast has been an extremely fruitful journey. The minichromosome maintenance (MCM) 2–7 genes that encode the catalytic core of the eukaryotic replisome were initially identified through forward ...
Bik-Kwoon Tye, Yuanliang Zhai
doaj +1 more source
Musculoskeletal Diseases: Mechanisms and Therapeutic Advances
MedComm, Volume 6, Issue 12, December 2025.Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma +17 more
wiley +1 more source
PLoS Genetics, 2016 The maintenance of chromosome integrity is crucial for genetic stability. However, programmed chromosome fragmentations are known to occur in many organisms, and in the ciliate Tetrahymena the five germline chromosomes are fragmented into hundreds of ...
Chih-Yi Gabriela Lin, I-Ting Lin, M. Yao
semanticscholar +1 more source
Cancer Medicine, Volume 14, Issue 22, November 2025.Here, our findings demonstrate that RNA‐binding proteins (RBPs) ZC3H12D and DDX5 antagonize breast tumor cell cycle progression by competitively regulating the mRNA stability and expression of cell cycle‐promoting genes via targeting the RNA stem–loop structure, which broadens our understanding of the RBPs‐mediated post‐transcriptional regulation of ...
Liang Sun, Xueting Liu, Wenbao Lu
wiley +1 more source
Journal of Biological Chemistry, 2015 Mcm10 is required for the initiation of eukaryotic DNA replication and contributes in some unknown way to the activation of the Cdc45-MCM-GINS (CMG) helicase.
M. Douglas, J. Diffley
semanticscholar +1 more source
Building Immunocompetent Cerebral Organoids From a Developmental Perspective
Glia, Volume 73, Issue 11, Page 2154-2166, November 2025.Main Points Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols.
Xabier Cuesta‐Puente +8 more
wiley +1 more source
Translational Oncology, 2016 BACKGROUND: Small intestinal neuroendocrine neoplasm (SI-NEN) proliferation is quantified by Ki67 measurements which capture G1-G2M phases of the cell cycle.
Simon Schimmack +5 more
doaj +1 more source
Molecular & Cellular Proteomics, 2015 The minichromosome maintenance complex (MCM) proteins are required for processive DNA replication and are a target of S-phase checkpoints. The eukaryotic MCM complex consists of six proteins (MCM2–7) that form a heterohexameric ring with DNA helicase ...
Romain Drissi +3 more
semanticscholar +1 more source
Molecular Nutrition &Food Research, Volume 69, Issue 22, November 2025.Early‐life exposure of rats to high‐fat‐isocaloric diet leads to metabolically obese, normal‐weight phenotype, and impaired cognition. Hippocampal transcriptomic analysis reveals disruption in pathways linked to obesity and cognitive decline, which is mitigated by perinatal leptin supplementation. PBMC share common altered genes with hippocampus, which
Carmen García‐Ruano +3 more
wiley +1 more source
The 5S RNA gene minichromosome of Euplotes [PDF]
Nucleic Acids Research, 1989 The macronucleus of the ciliated protozoan Euplotes eurystomus contains about 10(6) copies of a single type of 5S ribosomal RNA gene. This 5S gene DNA is only 930 bp long, is flanked by telomeres, and contains a single coding region of 120 bp which serves as a template for transcription in vivo and in vitro.
A E, Roberson +3 more
openaire +2 more sources