KSHV Genome Replication and Maintenance [PDF]
, 2016 Kaposi’s sarcoma associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8) is a major etiological agent for multiple severe malignancies in immunocompromised patients.
Namrata Gupta +4 more
core +3 more sources
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication
BioEssays, Volume 48, Issue 1, January 2026.Origin licensing constitutes the first step in initiating eukaryotic genome replication. Licensed origins are marked by an MCM double hexamer complex. This article reviews the molecular mechanisms of MCM double hexamer loading in yeast and higher eukaryotes, based on insights gained from biochemical reconstitution and structural analyses.
Victoria Frisbie, Franziska Bleichert
wiley +1 more source
Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. [PDF]
, 2011 RATIONALE: Recent work in animal models and humans has demonstrated the presence of organ-specific progenitor cells required for the regenerative capacity of the adult heart.
Bauer, Michael +15 more
core +2 more sources
International Journal of General Medicine, 2022 Ru Chen,1,2,* Bing Hu,1,* Ming Jiang,1,* Wen Deng,1 Ping Zheng,3 Bin Fu1,4 1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Department of Urology, The ...
Chen R +5 more
doaj
MUTANTS OF S. CEREVISIAE DEFECTIVE IN THE MAINTENANCE OF MINICHROMOSOMES [PDF]
Genetics, 1984 ABSTRACT We have isolated yeast mutants that are defective in the maintenance of circular minichromosomes. The minichromosomes are mitotically stable plasmids, each of which contains a different ARS (autonomously replicating sequence), a centrometeric sequence, CEN5, and two yeast genes, LEU2 and URA3.
Maine, Gregory T. +2 more
openaire +2 more sources
Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal +3 more
wiley +1 more source
Epigenetic Regulation of Hepatitis B Virus Covalently Closed Circular DNA: Implications for Epigenetic Therapy against Chronic Hepatitis B [PDF]
, 2017 Hepatitis B virus (HBV) infection represents a significant public health burden worldwide. Although current therapeutics manage to control the disease progression, lifelong treatment and surveillance are required because drug resistance develops during ...
Guo, Haitao, Hong, Xupeng, Kim, Elena S.
core +2 more sources
Schizosaccharomyces pombe Minichromosome Maintenance-binding Protein (MCM-BP) Antagonizes MCM Helicase [PDF]
Journal of Biological Chemistry, 2011 The minichromosome maintenance (MCM) complex, a replicative helicase, is a heterohexamer essential for DNA duplication and genome stability. We identified Schizosaccharomyces pombe mcb1(+) (Mcm-binding protein 1), an apparent orthologue of the human MCM-binding protein that associates with a subset of MCM complex proteins. mcb1(+) is an essential gene.
Lin, Ding, Susan L, Forsburg
openaire +2 more sources
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis
Glia, Volume 73, Issue 12, Page 2407-2426, December 2025.Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf +3 more
wiley +1 more source
Investigating Diagnostic Problems of CIN1 and CIN2 Associated With High-risk HPV by Combining the Novel Molecular Biomarker PanHPVE4 With P16INK4a. [PDF]
, 2015 Grading cervical intraepithelial neoplasia (CIN) determines clinical management of women after abnormal cytology with potential for overdiagnosis and overtreatment.
Arora, Rupali +13 more
core +2 more sources