Results 121 to 130 of about 1,224,373 (238)

SMC5/6-Mediated Transcriptional Regulation of Hepatitis B Virus and Its Therapeutic Potential

Viruses
Cells have developed various mechanisms to counteract viral infections. In an evolutionary arms race, cells mobilize cellular restriction factors to fight off viruses, targeted by viral factors to facilitate their own replication.
Johannes Bächer, Lena Allweiss, Maura Dandri   +2 more
doaj   +1 more source

Musculoskeletal Diseases: Mechanisms and Therapeutic Advances

MedComm, Volume 6, Issue 12, December 2025.
Musculoskeletal diseases comprise a broad spectrum of inflammatory, degenerative, and neoplastic disorders. Increasing evidence highlights the central role of immune regulation in their pathogenesis, with complex interactions among immune, bone, muscle, and stromal cells.
Xiao Ma, Eloy Yinwang, Xupeng Chai, Fangqian Wang, Zehao Chen, Shengdong Wang, Hao Zhou, Yucheng Xue, Jiangchu Lei, Fanglu Chen, Hengyuan Li, Shixin Chen, Shenzhi Zhao, Kelei Wang, Liang Chen, Junjie Gao, Zhaoming Ye, Nong Lin   +17 more
wiley   +1 more source

Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis

BMC Cancer, 2005
Background Minichromosome maintenance (MCM) proteins are essential for the initiation of DNA replication and have been found to be relevant markers for prognosis in a variety of tumours.
Wild Peter J, Tzankov Alexandar, Zimpfer Annette, Went Philip, Obermann Ellen C, Stoehr Robert, Pileri Stefano A, Dirnhofer Stephan   +7 more
doaj   +1 more source

ZC3H12D and DDX5 Antagonistically Regulate Cyclin D1 mRNA Stability and Cell Cycle Progression in Breast Cancer

Cancer Medicine, Volume 14, Issue 22, November 2025.
Here, our findings demonstrate that RNA‐binding proteins (RBPs) ZC3H12D and DDX5 antagonize breast tumor cell cycle progression by competitively regulating the mRNA stability and expression of cell cycle‐promoting genes via targeting the RNA stem–loop structure, which broadens our understanding of the RBPs‐mediated post‐transcriptional regulation of ...
Liang Sun, Xueting Liu, Wenbao Lu
wiley   +1 more source

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells [PDF]

, 2016
© 2016 the American Physiological Society. Airway remodeling is a hallmark feature of asthma and chronic obstructive pulmonary disease. Clinical studies and animal models have demonstrated increased airway smooth muscle (ASM) mass, and ASM thickness is ...
Deshpande, DA, Hershfeld, A, Kenyon, LC, Panebra, A, Pera, T, Sharma, P, Tiegs, BC   +6 more
core   +1 more source

Nuclear Prohibitin3 Maintains Genome Integrity and Cell Proliferation in the Root Meristem through Minichromosome Maintenance 21

Plant Physiology, 2019
The nuclear localized PROHIBITIN3 acts as a transcriptional co-regulator that sustains genome integrity and cell proliferation by directly suppressing the expression of MINICHROMOSOME MAINTENANCE 2.
Ruihuan Huang, Si Shu, Mengling Liu, Chao Wang, B. Jiang, Jieming Jiang, Chengwei Yang, Shengchun Zhang   +7 more
semanticscholar   +1 more source

Building Immunocompetent Cerebral Organoids From a Developmental Perspective

Glia, Volume 73, Issue 11, Page 2154-2166, November 2025.
Main Points Conventional cerebral organoids do not contain microglia, which must be added. We propose recommendations to assess microglial immunocompetence using quantitative approaches and stringent statistical analysis to help develop standardized protocols.
Xabier Cuesta‐Puente, Marco Gonzalez‐Dominguez, Marta Pereira‐Iglesias, Nerea Perez‐Arriazu, Patricia Villegas‐Zafra, Paula Ramos‐Gonzalez, Fabio Cavaliere, Nora Bengoa‐Vergniory, Amanda Sierra   +8 more
wiley   +1 more source

Meiotic behavior of small chromosomes in maize [PDF]

, 2013
The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine, and then separate at anaphase I. At anaphase II, sister chromatids separate.
Fangpu Han, James A. Birchler
core   +2 more sources

Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors

Anticancer Research, 2019
Background/Aim: Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors.
Michal Aporowicz, P. Czopnik, Eliza Kubicka, A. Piotrowska, P. Dzięgiel, M. Bolanowski, P. Domosławski   +6 more
semanticscholar   +1 more source

Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. [PDF]

PLoS Pathogens, 2010
Modulation of host DNA synthesis is essential for many viruses to establish productive infections and contributes to viral diseases. Human cytomegalovirus (HCMV), a large DNA virus, blocks host DNA synthesis and deregulates cell cycle progression.
Zhikang Qian, Van Leung-Pineda, Baoqin Xuan, Helen Piwnica-Worms, Dong Yu   +4 more
doaj   +1 more source