Results 141 to 150 of about 1,224,373 (238)

Minichromosome Maintenance Proteins Cooperate with LANA during the G1/S Phase of the Cell Cycle To Support Viral DNA Replication

Journal of Virology, 2019
LANA-mediated latent DNA replication is essential for efficient maintenance of KSHV episomes in the host. During latency, virus relies on the host cellular machinery for replication, which occurs in synchrony with the cellular DNA.
Prerna Dabral, T. Uppal, Cyprian C. Rossetto, S. Verma   +3 more
semanticscholar   +1 more source

Targeting c‐Myc enhances immunotherapy efficacy in combination with Ras inhibitor in triple‐negative breast cancer

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
1. Ras inhibition (Salirasib) combined with c‐Myc targeting blocks MCM2‐driven DNA replication, inducing cell‐cycle arrest and apoptosis. 2. Dual inhibition remodels the immunosuppressive TME, polarising macrophages to M1 and enhancing PD‐L1 blockade efficacy. 3.
Xiaojie Liang, Yiqiu Liu, Ye Zhu, Yuhan Zhao, Fan Ye, Fangyan Gao, Yaqin Shi, Xiaoxiang Guan   +7 more
wiley   +1 more source

Heterochromatin and RNAi Are Required to Establish CENP-A Chromatin at Centromeres [PDF]

, 2008
Heterochromatin is defined by distinct posttranslational modifications on histones, such as methylation of histone H3 at lysine 9 (H3K9), which allows heterochromatin protein 1 (HP1)–related chromodomain proteins to bind.
A. L. Pidoux, Allshire, Baum, Buhler, Cleveland, Grewal, H. D. Folco, Marschall, Morris, Noma, Nonaka, Partridge, Pidoux, R. C. Allshire, Saffery, Saitoh, Saitoh, Sullivan, Sullivan, T. Urano, Takahashi, Takahashi, Verdel   +22 more
core   +1 more source

mRNA expression of minichromosome maintenance 2 in colonic adenoma and adenocarcinoma

European Journal of Cancer Prevention, 2009
As proliferation is essential for progression from normal cells to tumor, certain markers specific to proliferating cells may permit detection of premalignant lesions. Here, we aimed to evaluate the possible value of a proliferation marker, minichromosome maintenance 2 (MCM2), in the early diagnosis of colorectal cancer, by analyzing the difference in ...
Wang, Yong, Li, Yuan, Zhang, Wen-Yan, Xia, Qing-Jie, Li, Hong-Guang, Wang, Rong, Yang, Lie, Sun, Xiao-Feng, Zhou, Zong-Guang   +8 more
openaire   +4 more sources

Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
Regarding the general picture of heart regeneration therapy, it encompasses exogenous cell therapy, endogenous medications, metabolism, interventions in gene pathways, as well as the therapeutic strategies in the burgeoning interdisciplinary field of medicine and engineering in recent years.
Mingchuan Liu, Tingwei Peng, Rui Yu, Kexin Wang, Di Wang, Xiaojie Jia, Yan Zhang, Jianqiang Hu, Bingchao Qi, Yan Li   +9 more
wiley   +1 more source

A conserved MCM single-stranded DNA binding element is essential for replication initiation [PDF]

, 2013
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA.
Abrahams, Afonine, Aparicio, Aravind, Atanassova, Bae, Barry, Barry, Bell, Bochman, Bochman, Brewster, Brunger, Brunger, Chan, Chong, Costa, Costa, Davey, Enemark, Enemark, Esnouf, Evrin, Fletcher, Fu, Gomez-Llorente, Heller, Ilves, Itsathitphaisarn, Kanemaki, Kaplan, Labib, Laskowski, Liu, Maiorano, McCoy, McGeoch, Merritt, Mossessova, Moyer, Neuwald, Otwinowski, Pape, Pucci, Pucci, Raghunathan, Randell, Remus, Remus, Sakakibara, Sanner, Schrodinger, Schwacha, Skordalakes, Takayama, Tanaka, Thomsen, Vagin, Vagin, Wei, Winn, Yardimci   +61 more
core   +2 more sources

Minichromosome maintenance protein 10 as a marker for proliferation and prognosis in lung cancer.

International Journal of Oncology, 2019
DNA replication is a vital process in cell division where anomalies can lead to tumorigenesis. Minichromosome maintenance complex component 10 (MCM10) plays a crucial role in this process. However, the role of MCM10 in lung cancer pathogenesis remains to
Meng Wang, S. Xie, wen yuan, Tian Xie, Muhammad Jamal, Jie Huang, Qian Yin, Heng-ya Song, Qiuping Zhang   +8 more
semanticscholar   +1 more source

HROB Induces Lung Adenocarcinoma Progression via ZC3HC1‐CCNB1 Axis Regulation and Cell Cycle Dysregulation

Cancer Science, Volume 116, Issue 10, Page 2699-2711, October 2025.
We have uncovered a novel mechanism by which HROB modulates cell proliferation in lung adenocarcinoma. Our findings suggest that HROB recruits ZC3HC1 and mediates its de‐phosphorylation at Ser354, which in turn promotes K27‐linked ubiquitination of CCNB1, leading to its proteasomal degradation.
Zhe Zhang, Cheng Wang, Yuanwei Guo, Zhenyu Zhao, Zhi Yang, Shouzhi Xie, Xinhang Hu, Xingchun Huang, Yupeng Jiang, Bing Xiao, Li Wang, Fenglei Yu, Bin Wang   +12 more
wiley   +1 more source

Resting cells rely on the DNA helicase component MCM2 to build cilia [PDF]

, 2019
Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number of MCM hexamers greatly exceeds the number of firing origins suggesting additional roles of MCMs. Here we
Alcantara, Alver, Amack, Amsterdam, Anders, Arnaiz, Avila, Bailey, Bailey, Belmont, Bentley, Bettencourt-Dias, Bicknell, Bochman, Bochman, Buenrostro, Burkhalter, Campos, Casar Tena, Chen, Chuang, Cornelia Donow, Dasgupta, Drissi, Dubois, Essner, Evrin, Ferguson, Gerdes, Gineau, Goetz, Grimes, Hamada, Hemerly, Hiraga, Holland, Hughes, Ibarra, Ishikawa, Ishimi, Karol Szafranski, Kim, Kim, Kong, Kunnev, Labib, Langley, Langmead, Lars D Maerz, Li, Li, Liao, Long, Mahjoub, Maine, Marco Groth, Maric, Maric, Marshall, Martin D Burkhalter, Melanie Philipp, Micklem, Miotto, Mukhopadhyay, Mullee, Nguyen, Paul Walther, Penelope A Jeggo, Petryk, Philipp, Philipp, Prasanth, Praveen, Prioleau, Prokhortchouk, Pruitt, Pugacheva, Rainey, Rice, Robinson, Rusiniak, Ruzov, Ruzov, Sabrina Matysik, Sanchez, Schneider, Sheu, Shukla, Soung, Stelzer, Stiff, Stiff, Stuermer, Sugimoto, Takahashi, Tamara J Blätte, Tanos, Tena, Teresa Casar Tena, Thisse, Todorov, Vijayraghavan, Walther, Wei, Zhang, Zhang, Zhou   +106 more
core   +1 more source

Supplementary Figure 1 from Regulation of Minichromosome Maintenance Gene Family by MicroRNA-1296 and Genistein in Prostate Cancer [PDF]

, 2023
Shahana Majid, Altaf A. Dar, Sharanjot Saini, Yi Chen, Varahram Shahryari, Jan Liu, Mohd Saif Zaman, Hiroshi Hirata, Soichiro Yamamura, Koji Ueno, Yuichiro Tanaka, Rajvir Dahiya   +11 more
openalex   +1 more source