Results 151 to 160 of about 1,224,373 (238)
Recent evidence that TADs and chromatin loops are dynamic structures. [PDF]
, 2017 Mammalian genomes are folded into spatial domains, which regulate gene expression by modulating enhancer-promoter contacts. Here, we review recent studies on the structure and function of Topologically Associating Domains (TADs) and chromatin loops.
Cattoglio, Claudia +3 more
core +1 more source
Folia Histochemica et Cytobiologica, 2011 In the present study, nuclear proliferative proteins: MCM2, MCM5, MCM7, Ki-67 and AgNORs expression was assessed in paraffin sections from sporadic desmoid tumours using a tissue microarray (TMA)-based immuno- and histochemistry, respectively.
Dobrosława Lopaczyńska +8 more
doaj +1 more source
Prognostic significance of minichromosome maintenance proteins in breast cancer.
American journal of cancer research, 2015 A role for the minichromosome maintenance (MCM) proteins in cancer initiation and progression is slowly emerging. Functioning as a complex to ensure a single chromosomal replication per cell cycle, the six family members have been implicated in several neoplastic disease states, including breast cancer.
Yuen, HF +7 more
openaire +4 more sources
Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro [PDF]
, 2002 Cdc6p is a key regulator of the cell cycle in eukaryotes and is a member of the AAA(+) (ATPases associated with a variety of cellular activities) family of proteins.
Mizushima, T. +4 more
core +1 more source
Proliferative activity of extracellular HIV-1 Tat protein in human epithelialcells: expression profile of pathogenetically relevant genes [PDF]
, 2015 5noBACKGROUND: Tat is being tested as a component of HIV vaccines. Tat activity has been mainly investigated on cells of lymphoid/hematopoietic lineages. HIV-1, however, is known to infect many different cells of both solid organs and mucosal surfaces.
core
miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis [PDF]
, 2014 BACKGROUND: As a distinctive type of head and neck cancers, nasopharyngeal carcinoma (NPC) is genesis from the clonal Epstein-Barr virus (EBV)-infected nasopharyngeal epithelial cells accumulated with multiple genetic lesions. Among the recurrent genetic
Busson, P +12 more
core +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the functional impact of minichromosome maintenance protein 7 (MCM7) silencing on cutaneous malignant melanoma (CMM) cell apoptosis and proliferation via AKT signaling pathway.
TANG Hua +6 more
doaj +1 more source
Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014 [PDF]
, 2016 Primary heart tumours affect less than 1% of dogs. Due to their rare incidence, every research showing the frequency of cardiac tumours is valuable. Routine diagnostics is often complemented with immunohistochemical analysis.
Ciaputa, Rafał +8 more
core +1 more source
Journal of Cancer, 2018 Background: The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC).
Xiwen Liao +15 more
semanticscholar +1 more source
Proteomic alterations in early stage cervical cancer [PDF]
, 2018 Laser capture microdissection (LCM) allows the capture of cell types or well-defined structures in tissue. We compared in a semi-quantitative way the proteomes from an equivalent of 8,000 tumor cells from patients with squamous cell cervical cancer (SCC,
Bischoff, Rainer +11 more
core +5 more sources