Results 41 to 50 of about 1,205,791 (198)

MCM4 is a novel prognostic biomarker and promotes cancer cell growth in glioma

open access: yesFrontiers in Oncology, 2022
BackgroundGliomas account for 75% of all primary malignant brain tumors in adults and result in high mortality. Accumulated evidence has declared the minichromosome maintenance protein complex (MCM) gene family plays a critical role in modulating the ...
Shu Yang   +9 more
doaj   +1 more source

Molecular functions of MCM8 and MCM9 and their associated pathologies

open access: yesiScience, 2023
Summary: Minichromosome Maintenance 8 Homologous Recombination Repair Factor (MCM8) and Minichromosome Maintenance 9 Homologous Recombination Repair Factor (MCM9) are recently discovered minichromosome maintenance proteins and are implicated in multiple ...
Noah Cornelis Helderman   +9 more
doaj   +1 more source

Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress

open access: yesG3: Genes, Genomes, Genetics, 2022
Upon replication stress, ssDNA, coated by the ssDNA-binding protein RPA, accumulates and generates a signal to activate the replication stress response. Severe replication stress induced by the loss of minichromosome maintenance helicase subunit Mcm4 in ...
Seong Min Kim, Susan L Forsburg
doaj   +1 more source

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

open access: yesNature Communications, 2021
Minichromosome maintenance protein 10 (MCM10) is critical for eukaryotic DNA replication. Here, by modelling MCM10 variants in human cell lines, the authors reveal a mechanism of MCM10-associated disease, finding that loss of MCM10 function constrains ...
Ryan M. Baxley   +25 more
doaj   +1 more source

Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program [PDF]

open access: goldRetrovirology, 2011
Willems Luc   +4 more
doaj   +2 more sources

Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure. [PDF]

open access: yesPLoS ONE, 2008
Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subunits.
Alexandra Surcel   +3 more
doaj   +1 more source

Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]

open access: yes, 2013
Peer reviewedPublisher ...
Martin, Samuel A.M.   +3 more
core   +2 more sources

Potential Prospective Biomarkers for Non-small Cell Lung Cancer: Mini-Chromosome Maintenance Proteins

open access: yesFrontiers in Genetics, 2021
Minichromosome maintenance proteins (MCMs) are considered to be essential factors coupling DNA replication to both cell cycle progression and checkpoint regulation. Previous studies have shown that dysregulation of MCMs are implicated in tumorigenesis of
Chen Huang   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy