Regulation of Minichromosome Maintenance Helicase Activity by Cdc6 [PDF]
Journal of Biological Chemistry, 2003 Genetic studies, together with amino acid and structural similarities to the clamp loaders of DNA polymerase sliding clamps, have suggested that the Cdc6 protein may function as a loader for the eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex.
Jae‐Ho Shin +4 more
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Expression of Minichromosome Maintenance Proteins (MCM) and Cancer Prognosis: A meta-analysis [PDF]
J Cancer, 2018 Minichromosome maintenance proteins (MCM) played a critical role in replication and cell cycle progression. However, their prognostic roles in cancer remain controversial.
K. Gou +5 more
semanticscholar +2 more sources
Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program [PDF]
Retrovirology, 2011 Mathieu Boxus +4 more
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Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks [PDF]
Cell Cycle, 2018 DNA replication during S phase involves thousands of replication forks that must be coordinated to ensure that every DNA section is replicated only once.
Romain Drissi +6 more
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MCM4 is a novel prognostic biomarker and promotes cancer cell growth in glioma
Frontiers in Oncology, 2022 BackgroundGliomas account for 75% of all primary malignant brain tumors in adults and result in high mortality. Accumulated evidence has declared the minichromosome maintenance protein complex (MCM) gene family plays a critical role in modulating the ...
Shu Yang +9 more
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Molecular functions of MCM8 and MCM9 and their associated pathologies
iScience, 2023 Summary: Minichromosome Maintenance 8 Homologous Recombination Repair Factor (MCM8) and Minichromosome Maintenance 9 Homologous Recombination Repair Factor (MCM9) are recently discovered minichromosome maintenance proteins and are implicated in multiple ...
Noah Cornelis Helderman +9 more
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Minichromosome maintenance (MCM) proteins may be pre-cancer markers [PDF]
Gut, 2002 Aberrant overexpression of proteins called minichromosome maintenance (Mcm) proteins at the mucosal surface of dysplastic oesophageal squamous epithelium and Barrett's mucosa may indicate proliferation potential Oesophageal cancer contributes about 3% of the cancer burden in the UK, 5% of cancer mortality, and the five year survival is a dismal 6 ...
Malcolm Alison, T Hunt, S J Forbes
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Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress
G3: Genes, Genomes, Genetics, 2022 Upon replication stress, ssDNA, coated by the ssDNA-binding protein RPA, accumulates and generates a signal to activate the replication stress response. Severe replication stress induced by the loss of minichromosome maintenance helicase subunit Mcm4 in ...
Seong Min Kim, Susan L Forsburg
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Gynecological Endocrinology, 2023 Purpose To investigate whether mutations in the minichromosome maintenance complex component (MCM) family genes were present in patients with polycystic ovary syndrome (PCOS) of Chinese descent.
Jiangyan Zhou +12 more
semanticscholar +1 more source
Bioinformatics Analysis Reveals that Minichromosome Maintenance 10 Replication Initiation Factor Is a Possible Prognostic Marker for Patients With Adrenocortical Carcinoma [PDF]
Cancer Diagn PrognSHIN-NOSUKE YAMASHITA +10 more
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