Results 51 to 60 of about 1,224,373 (238)

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

open access: yesNature Communications, 2021
Minichromosome maintenance protein 10 (MCM10) is critical for eukaryotic DNA replication. Here, by modelling MCM10 variants in human cell lines, the authors reveal a mechanism of MCM10-associated disease, finding that loss of MCM10 function constrains ...
Ryan M. Baxley   +25 more
doaj   +1 more source

Minichromosome maintenance protein in myxofibrosarcoma [PDF]

open access: yesModern Pathology, 2003
Histopathological assessment of myxofibrosarcoma may be difficult, especially on the basis of a small core biopsy, which enables only a crude evaluation of grade and prognosis. We have tested the hypothesis that determination of cell cycle state may assist in the diagnostic assessment of myxofibrosarcoma.
Sington, James D.   +6 more
openaire   +3 more sources

The Minichromosome Maintenance Replicative Helicase [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2013
The eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex, is composed of six distinct, but related, subunits MCM(2-7). The relationship between the sequences of the subunits indicates that they are derived from a common ancestor and indeed, present-day archaea possess a homohexameric MCM.
Stephen D, Bell, Michael R, Botchan
openaire   +2 more sources

MCM5 (minichromosome maintenance complex component 5) [PDF]

open access: yesAtlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Published in Atlas Database: July 2011 Online updated version : http://AtlasGeneticsOncology.org/Genes/MCM5ID41321ch22q12.html DOI: 10.4267/2042/46072 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
Kontos, CK, Pavlou, MAS, Giaginis, C
openaire   +2 more sources

Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure. [PDF]

open access: yesPLoS ONE, 2008
Cohesin is the protein complex responsible for maintaining sister chromatid cohesion. Cohesin interacts with centromeres and specific loci along chromosome arms known as Chromosome Attachment Regions (CARs). The cohesin holocomplex contains four subunits.
Alexandra Surcel   +3 more
doaj   +1 more source

An archaeal order with multiple minichromosome maintenance genes [PDF]

open access: yesMicrobiology, 2010
In eukaryotes, a complex of six highly related minichromosome maintenance (MCM) proteins is believed to function as the replicative helicase. Until recently, systems for exploring the molecular mechanisms underlying eukaryotic MCM function have been biochemically intractable.
Alison D, Walters, James P J, Chong
openaire   +2 more sources

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

open access: yes, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V   +9 more
core   +2 more sources

Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]

open access: yes, 2013
Peer reviewedPublisher ...
Martin, Samuel A.M.   +3 more
core   +2 more sources

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