Results 61 to 70 of about 1,205,791 (198)

Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology. [PDF]

, 2013
Deregulation of mini-chromosome maintenance (MCM) proteins is associated with genomic instability and cancer. MCM complexes are recruited to replication origins for genome duplication.
Brewster, Aaron, Chen, Xiaojiang S, Forsburg, Susan L, Fu, Yang, Ranatunga, Nimna, Slaymaker, Ian M, Toso, Daniel B, Zhou, Z Hong   +7 more
core   +1 more source

Homologous Recombination: To Fork and Beyond [PDF]

, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core   +1 more source

The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in the Uterine Fibroids

Current Issues in Molecular Biology, 2021
Uterine fibroids are the most common mesenchymal uterine neoplasms; their prevalence is estimated in 40%–60% of women under 35 and in 70%–80% of women over 50 years of age.
Piotr Rubisz, Lidia Hirnle, Christopher Kobierzycki   +2 more
doaj   +1 more source

Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere. [PDF]

, 2018
In addition to its roles in transcription and replication, topoisomerase 2 (topo 2) is crucial in shaping mitotic chromosomes and in ensuring the orderly separation of sister chromatids.
Farr, Christine J, Fukagawa, Tatsuo, Mills, Walter E, Spence, Jennifer M   +3 more
core   +1 more source

Minichromosome maintenance 2 and 5 expressions are increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities

Clinics, 2011
INTRODUCTION: Gingiva fibromatosis is a relatively rare condition characterized by diffuse enlargement of the gingiva, which is caused by expansion and accumulation of the connective tissue.
Hercílio Martelli-Júnior, Carolina de Oliveira Santos, Paulo Rogério Bonan, Paula de Figueiredo Moura, Carolina Cavalcante Bitu, Jorge Esquiche León, Ricardo D. Coletta   +6 more
doaj   +1 more source

Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma [PDF]

, 2017
The present study aimed to ascertain the significance of topoisomerase II alpha (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma.
Adhemar Longatto-Filho, Adriana Lorenzi, Allini Mafra, Armando G.F. Melani, Bala, Bean, Brown, Carlos Veo, Cristina Mendes de Oliveira, Cristovam Scapulatempo-Neto, Edgar Antonio Alemán Loaiza, Filho, Filho, Firnhaber, Grulich, José Eduardo Levi, José Humberto T.G. Fregnani, Kreuter, Legarth, Longacre, Luciana Albina Reis Rosa, Machalek, Nielsen, Palefsky, Pinto, Pirog, Roelens, Roldán Urgoiti, Saiki, Salit, Serup-Hansen, Shi, Thomas, Valari, Veo, Walboomers, Walts, Wentzensen, Wong, Zandberg   +39 more
core   +1 more source

Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2 [PDF]

Acta Radiologica, 2019
Wenjing Gao, Xiao Wang, Fuyan Li, Wenqi Shi, Hongxia Li, Qingshi Zeng   +5 more
semanticscholar   +2 more sources

High-Throughput Screening and Molecular Dynamics Simulation of Natural Products for the Identification of Anticancer Agents against MCM7 Protein

Applied Bionics and Biomechanics, 2022
Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome maintenance family that is necessary for the initiation of eukaryotic DNA replication.
Xin Zhang, Hui Chen, Hui Lin, Ronglan Wen, Fan Yang   +4 more
doaj   +1 more source

SWI/SNF-like chromatin remodeling factor Fun30 supports point centromere function in S. cerevisiae [PDF]

, 2011
Budding yeast centromeres are sequence-defined point centromeres and are, unlike in many other organisms, not embedded in heterochromatin. Here we show that Fun30, a poorly understood SWI/SNF-like chromatin remodeling factor conserved in humans ...
Anna T. Vetter, Beth A. Sullivan, Delphine Theodorou, Edoardo Petrini, Felix Krueger, J. Ross Miller, Konrad Paszkiewicz, Margaret R. Crawford, Mickaël Durand-Dubief, Nicholas A. Kent, Patrick Varga-Weisz, Rachael R. Harris, Rosa Maria Correra, William Ryan Will   +13 more
core   +4 more sources

The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]

, 2017
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Bai, Yuchen, Kwok, Hang Fai, Mahadevappa, Ravikiran, McCrudden, Cian M, Neves, Henrique, Wen, Qing, Yuen, Hiu Fung, Yuen, Shun Ming, Zhang, Shu Dong   +8 more
core   +3 more sources