Results 61 to 70 of about 1,224,373 (238)

Potential Prospective Biomarkers for Non-small Cell Lung Cancer: Mini-Chromosome Maintenance Proteins

Frontiers in Genetics, 2021
Minichromosome maintenance proteins (MCMs) are considered to be essential factors coupling DNA replication to both cell cycle progression and checkpoint regulation. Previous studies have shown that dysregulation of MCMs are implicated in tumorigenesis of
Chen Huang, Chuqi Lei, Boyu Pan, Senbiao Fang, Yubao Chen, Wenfeng Cao, Liren Liu   +6 more
doaj   +1 more source

Binding of Human Minichromosome Maintenance Proteins with Histone H3 [PDF]

Journal of Biological Chemistry, 1996
Minichromosome maintenance (MCM) proteins play essential roles in eukaryotic DNA replication, but their biochemical properties remain to be determined. We detected in HeLa cell extracts six proteins, CDC47, CDC46/MCM5, Cdc21, P1/MCM3, Mis5, and BM28/MCM2, by their binding to a specific antibody and by partial sequencing. The human homologs of the MCM2 (
Y, Ishimi, S, Ichinose, A, Omori, K, Sato, H, Kimura   +4 more
openaire   +2 more sources

Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: A gene required for repair of double strand break and recombination [PDF]

, 1995
A new Schizosaccharomyces pombe mutant (rad32) which is sensitive to gamma and UV irradiation is described. Pulsed field gel electrophoresis of DNA from irradiated cells indicates that the rad32 mutant, in comparison to wild type cells, has decreased ...
Nasim, Anwar, Shayeghi, Maryam, Tavassoli, Manoochehr, Watts, Felicity Z   +3 more
core   +2 more sources

Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas [PDF]

, 2009
Proteins necessary for the normal regulation of the cell cycle include minichromosome maintenance protein 2 (Mcm2) and geminin. These are overexpressed in several premalignant and malignant tumours.
A Freeman, A Ibarra, A Quaglia, A Shetty, A Torres-Rendon, EM Diaz Jr, G T Craig, G Xouri, GH Williams, GH Williams, I Kodani, I Kodani, IS Scott, IT Todorov, J Gerdes, J Mork, JA Wohlschlegel, JJ Going, K Stoeber, KK Tachibana, KL Eward, L Barnes, MA Gonzalez, MR Alison, MV Meng, NC Lea, P Chatrath, P M Speight, S Roy, SB Wharton, SB Wharton, SE Kearsey, SR Kingsbury, SS Napier, T Takeda, TJ Dudderidge, TJ McGarry   +36 more
core   +2 more sources

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology [PDF]

, 2017
Background: Biliary brush cytology is the standard method of evaluating biliary strictures, but is insensitive at detecting malignancy. In pancreaticobiliary cancer minichromosome maintenance replication proteins (MCM 2–7) are dysregulated in the ...
Chapman, MH, Huggett, MT, Johnson, GJ, Keane, MG, Mackay, J, Pereira, SP, Thorburn, D, Webster, GJ   +7 more
core   +1 more source

Microarray analysis of canine papillomavirus lesions [PDF]

, 2013
Papillomaviren verursachen eine breite Palette von Krankheitsbildern bei Mensch und Tier, welche von asymptomatischen Infektionen, gutartigen Warzen, pigmentierten Plaques, in situ Karzinomen bis zu invasiven Plattenepithelkarzinomen reichen.
Vetsch, Elisabeth
core   +1 more source

cccDNA Surrogate MC-HBV–Based Screen Identifies Cohesin Complex as a Novel HBV Restriction FactorSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV), existing as a stable minichromosome in the hepatocyte, is responsible for persistent HBV infection.
Zhuanchang Wu, Liyuan Wang, Xin Wang, Yang Sun, Haoran Li, Zhaoying Zhang, Caiyue Ren, Xiaohui Zhang, Shuangjie Li, Jinghui Lu, Leiqi Xu, Xuetian Yue, Yue Hong, Qiang Li, Haizhen Zhu, Yaoqin Gong, Chengjiang Gao, Huili Hu, Lifen Gao, Xiaohong Liang, Chunhong Ma   +20 more
doaj   +1 more source

Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer

npj Breast Cancer, 2017
Personalized medicine: Mutated tumors respond to therapy Mutations in the p53 tumor suppressor gene could offer a predictive biomarker of response to certain drugs in triple-negative breast cancer.
Wei-Gang Qiu, Alla Polotskaia, Gu Xiao, Lia Di, Yuhan Zhao, Wenwei Hu, John Philip, Ronald C. Hendrickson, Jill Bargonetti   +8 more
doaj   +1 more source

Minichromosome Maintenance Proteins as Markers for Proliferation Zones During Embryogenesis [PDF]

Cell Cycle, 2006
Regulation of cell proliferation is of fundamental importance for growth and prevention of cancer. An obligatory step in the regulation of cell proliferation is the control of the initiation of DNA synthesis. The minichromosome maintenance (MCM) proteins are essential DNA replication factors crucial for initiating DNA synthesis once every cell cycle ...
Ryu, Soojin, Driever, Wolfgang
openaire   +4 more sources

Double-strand break repair and homologous recombination in Schizosaccharomyces pombe [PDF]

, 2006
In recent years our understanding of double strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased ...
Ahmad, Ahmad, Ahn, Ahnesorg, Akamatsu, Assenmacher, Baumann, Boddy, Boddy, Bonatto, Bransteitter, Buck, Callebaut, Caspari, Catlett, Cervantes, Chahwan, Cheok, Connelly, Cooper, Doe, Doe, Doe, Doe, Dudasova, Farah, Farah, Ferreira, Ferreira, Fukushima, Gaillard, Goedecke, Goodwin, Grishchuk, Haber, Hartsuiker, Hefferin, Jang, Jung, Khasanov, Khasanov, Kibe, Kim, Kim, Krogh, Lambert, Laursen, Macris, Maftahi, Maftahi, Manolis, Marchetti, Martin, McGlynn, Moore, Morishita, Muris, Muris, Muris, Murray, Nakada, Nakamura, Oakley, Ono, Osman, Osman, Osman, Ostermann, Paques, Parker, Prudden, Sauvageau, Schmidt, Segurado, Shinohara, Smith, Steiner, Stewart, Sung, Suto, Szankasi, Szostak, Tarsounas, Tavassoli, Thacker, Tomita, Tomita, Tsutsui, Tsutsui, Ueno, van den Bosch, van den Bosch, Virgin, Virgin, Wang, Weterings, Whitby, Whitby, Wilson, Win, Win, You, Young   +102 more
core   +2 more sources