Results 91 to 100 of about 13,357,463 (271)
SP0135 HOW TO DIFFERENTIATE MINIMAL DISEASE ACTIVITY IN RA + DEMO [PDF]
Annals of the Rheumatic Diseases, 2019 Ultrasound (US) is increasingly utilised as a point-of-care tool to diagnose early inflammatory joint disease, monitor treatment response and detect subclinical inflammation. This is feasible as US can detect joint, and tendon, inflammation before it becomes clinically apparent.
openaire +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
SP0069 HOW TO DIFFERENTIATE MINIMAL DISEASE ACTIVITY IN RA + DEMO [PDF]
Annals of the Rheumatic Diseases, 2019 Ultrasound (US) is increasingly utilised as a point-of-care tool to diagnose early inflammatory joint disease, monitor treatment response and detect subclinical inflammation. This is feasible as US can detect joint, and tendon, inflammation before it becomes clinically apparent.
openaire +1 more source
Clinical Kidney JournalABSTRACT Background In contrast to childhood minimal change disease (MCD), adult-onset MCD frequently recurs and requires prolonged immunosuppressive therapy. Accordingly, an investigation of the pathogenesis of adult MCD is required. MCD is usually accompanied by severe dyslipidaemia.
Yuki Kajio +6 more
openaire +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
, 2018 Supplement_Moy_10.9.18 for Physical activity in COPD: Minimal clinically important difference for medical events by Merilee Teylan, Ana Kantorowski, Diana Homsy, Reema Kadri, Caroline Richardson, and Marilyn Moy in Chronic Respiratory ...
Reema Kadri (4460215) +5 more
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Acta Dermato-VenereologicaAbrocitinib, an oral selective Janus kinase 1 inhibitor, is approved for the treatment of moderate-tosevere atopic dermatitis (AD) in adults, but realworld evidence remains limited.
Elena Pezzolo +34 more
doaj +1 more source