Results 81 to 90 of about 13,357,463 (271)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Persistent Disease Activity in Patients With Long-Standing Glomerular Disease

, 2020
Glomerular diseases are characterized by variable disease activity over many years. We aimed to analyze the relationship between clinical disease activity and duration of glomerular disease. Disease activity in adults with chronic minimal change disease,
Sanghani, Neil S, Mu, Xueru, Chatterjee, Debanjana, Gibson, Keisha L, Piva, Stacy E, Canetta, Pietro A, Kil, Byum Hee, Gharavi, Ali G, Laurin, Louis-Philippe, Marasa, Maddalena, Nachman, Patrick H, Hladunewich, Michelle A, Kidd, Jason M, Rizk, Dana V, Julian, Bruce A, Wenderfer, Scott E, Hogan, Jonathan J, Rheault, Michelle N, Trachtman, Howard, Bomback, Andrew S, Delbarba, Elisa   +20 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Low disease activity state in rheumatoid arthritis:Concepts and derivation of minimal disease activity

, 2006
With recent advances in therapy, the proportion of patients achieving a satisfactory state of minimal disease activity (MDA) is becoming a more important measure with which to compare different treatment strategies.
Wells, George, Bombardier, Clair, Wolfe, Fred, Furst, Dan, Tugwell, Peter, Michaud, Kaleb, Anderson, Jennifer, Strand, Vibeke, van Riel, Piet, Boers, Maarten, Felson, David, Suarez-Almazor, Maria, Dougados, Maxime, Shea, Beverley, Kirwan, John, Landewé, Robert, Johnson, Kent, Hazes, Mieke, Aletaha, Daniel, Smolen, Josef, Lassere, Marissa, Simon, Lee, van der Heijde, Desiree, Brooks, Peter, Silman, Alan, Fransen, Jaap, Emery, Paul   +26 more
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The activity of amyloid beta binding alcohol dehydrogenase in Alzheimer's disease [PDF]

, 2012
The mitochondria are a vibrant hub for many problems that occur in Alzheimer’s disease. The enzyme amyloid-ß binding alcohol dehydrogenase (ABAD) and Cyclophilin D (CypD) are two key mitochondrial proteins that have essential functions in Alzheimer’s ...
Allen, Zoe Eleanor
core   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Minimal Important Difference (MID), Minimal Detectable Change (MDC), and Disease Activity Thresholds for Two Novel Composite Instruments (3 VAS, 4 VAS) in Patients with Psoriatic Arthritis: Pooled Analysis of Three Phase 3 Studies

, 2023
Background Though continuous composite measures of disease activity for psoriatic arthritis (PsA) assessment exist, abbreviated measures that are more feasible for screening in routine clinical practice are needed.
Perate, M, Vis, M, Nash, P, Coates, L, Soriano, E, Rampakakis, E, Shawi, M, Sharaf, M, Helliwell, P, Merola, JF, Tillett, W, Zimmermann, M   +11 more
core   +1 more source

A real-life study of juvenile idiopathic arthritis from two Brazilian referral centers for pediatric rheumatology

Advances in Rheumatology
Background Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood, but its outcomes are still difficult to determine. We aimed to obtain outcome measurements of disease activity, functional capacity, disease damage, and ...
Ana María Loroño Terrazas, Raúl Gutiérrez Suárez, Reinan Tavares Campos, Claudio Arnaldo Len, Nadia Emi Aikawa, Jade Dib Fernandez, Mayra Lisyer Dantas, Clóvis Artur Silva, Gleice Clemente, Maria Teresa Terreri   +9 more
doaj   +1 more source