Results 101 to 110 of about 13,357,463 (271)

Defining Minimal Disease Activity in Hidradenitis Suppurativa: A New Clinical Target

Journal of Cutaneous Medicine and Surgery
Background: Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease lacking a standardized definition of disease control. While minimal disease activity (MDA) serves as a validated treatment target in psoriasis and atopic dermatitis, no equivalent framework exists for HS, limiting the ...
Carmen García-Moronta, Francisco Javier León-Pérez, Andrea Isabel Rodríguez-Sanna, Julia Castro-Martín, Alberto Soto-Moreno, Salvador Arias-Santiago, Alejandro Molina-Leyva   +6 more
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Physical activity evaluation handbook [PDF]

U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Nutrition and Physical Activity.Spiral-bound.Also available ...
National Center for Chronic Disease Prevention and Health Promotion (U.S.)
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Remission, minimal disease activity, and acceptable symptom state in juvenile idiopathic arthritis: Defining criteria based on the juvenile arthritis disease activity score

, 2012
To determine cutoff values for defining remission, minimal disease activity, and parent and child acceptable symptom state in juvenile idiopathic arthritis (JIA) using the Juvenile Arthritis Disease Activity Score (JADAS).For the selection of cutoff ...
S. Magni Manzoni, N. Ruperto, A. Pistorio, Ravelli, Angelo, Consolaro, Alessandro, Malattia, Clara, Bracciolini, Giulia Patrizia, Martini, Alberto, Pederzoli, Silvia Maria Rita, S. Davì   +9 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

What are the main barriers to achieve minimal disease activity in psoriatic arthritis in real life?

, 2019
Minimal disease activity (MDA) is an important target in patients with psoriatic arthritis (PsA), however it is also criticised for having a low threshold for patient reported outcomes (PRO).The aim of the study was to assess the prevalence of MDA and ...
Yildiz, Fatih, Yıldız, Fatih, Kılıç, Levent, Kilic, Levent, Tufan, Abdurrahman, Esmen, Serpil Ergulu, Erden, Abdulsamed, Dalkilic, Ediz, Özişler, C., Aydın, Sibel Zehra, Al Osaimi, Noura, Omma, Ahmet, Bakirci, Sibel, Küçük, A., Aydin, Sibel Zehra, Küçük, Adem, Cinar, Muhammet, Kalyoncu, Umut, Bakırcı, Sibel, Doğru, Atalay, Can, Meryem, Akar, Servet, Ozisler, Cem, Çınar, Muhammet, Erden, Abdulsamet, Solmaz, Dilek   +25 more
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MCID/Low Disease Activity State Workshop: summary, recommendations, and research agenda.

, 2003
Item does not contain fulltextThe OMERACT 6 Minimal Clinically Important Difference/Low Disease Activity Workshop was organized with the aim of meeting the many challenges that exist in determining a low disease activity in rheumatoid arthritis (RA ...
Kirwan, J., Wells, George, Riel, P.L.C.M. van, Boers, M., Johnson, K., Anderson, J., Tugwell, Peter, Anderson, Jennifer, Strand, Vibeke, Boers, Maarten, Shea, Bev, Felson, David, Simon, L.S., Shea, Beverley, Van Riel, Piet, Kirwan, John, Heiberg, T., Johnson, Kent, Stran, Vibeke, Lassere, M.N., Heilberg, Turid, Lassere, Marissa, Robinson, Vivian, Kirwan, John R., Simon, Lee, Robinson, V., Strand, V., Felson, D.T., Tugwell, P.S., Hewlett, Sarah, Wells, G.A., Hewlett, S., Shea, B., Heiberg, Turid   +33 more
core   +4 more sources

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Leptin serum and disease activity in spondyloarthritis [PDF]

, 2020
Background: Spondyloarthritis (SpA) is an active chronic inflammatory disease involving pro-inflammatory cytokines; one of which is leptin. This study aimed to determine correlation between leptin serum level and disease activity in SpA patients. Method:
Luluch Mulyani, Yuliasih
core   +1 more source