Results 141 to 150 of about 323,063 (310)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Minimal Element of Writing

Jacques Derrida claims that the mark constitutes the minimal element of writing — what he calls ‘the irreducible atom’1 at the asemic origin for the metaphysics of meaning itself (be this origin in the biogenetic code of life or the cybernetic code of ...
Book, C
core  

MINIMAL ENUMERATIONS

, 1997
The work covers the minimal calculated enumerations in the families of the recursive-enumerated sets. The aim is to find the internal criteria for minimality of enumerations, to develop the effective methods for construction of the minimal-calculated ...
Badaev, Serikdjan Agybaevich, The Institute of Theoretical and Applied Mathematics, Kazakh National Academy of Sciences (Russian Federation)   +1 more
core  

Application of hybrid Trefftz finite element method to non-linear problems of minimal surface

, 2015
This investigation provides a hybrid Trefftz finite element approach for analysing minimal surface problems. The approach is based on combining Trefftz finite element formulation with radial basis functions (RBF) and the analogue equation method (AEM ...
Arounsavat, Detdexa, Wang, Hui, Qin, Qing Hua   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Multiscale modelling and an experimental investigation on size-scale effects in concrete

, 2010
Includes abstract.Includes bibliographical references (leaves 82-90).Classical continuum mechanics assumes that constitutive parameters are associated with a so-called Representative Volume Element (RVE) and are a statistical average.
Braun, Simon
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Minimal ∗-varieties and superinvolutions

We introduce a class of finite dimensional superalgebras over an algebraically closed field of characteristic zero, whose Grassmann envelopes generate all $\ast$-minimal varieties.
Di Vincenzo O. M., Nardozza, Vincenzo C., Di Vincenzo, Onofrio M., Nardozza Vincenzo   +3 more
core   +1 more source

The decompositions of elements of the lattice with minimal condition [PDF]

Časopis pro pěstování matematiky, 1955
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source