Results 81 to 90 of about 323,063 (310)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Micromechanical response of fibre-reinforced materials using the boundary element technique
, 2003 The Boundary Element Method (BEM) and the Embedded Cell Approach (ECA) have been used to analyse the effects of constituent material properties and fibre spatial distribution on the localised behaviour of a transversely loaded, unidirectional fibre ...
Knight, MG, Wrobel, LC, Henshall, JL
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Minimal example of finite element method for the spectral fractional Laplacian in FEniCSx
, 2022 A minimal example of adaptive finite element method for the two-dimensional spectral fractional Laplacian based on the FEniCSx library FEniCS-Error-Estimation (FEniCS-EE) is provided.FEniCS-EE is an open source library showing how hierarchical ...
Jack S. Hale (2928321) +1 more
core +1 more source
Convergence of Minimal and Approximate Minimal Elements of Sets in Partially Ordered Vector Spaces
Journal of Mathematical Analysis and Applications, 1999 Let \(Z\) be a real normed vector space partially ordered by a closed convex pointed cone \(C\) with nonempty interior, and let \(A\) be a nonempty set in \(Z\). In the first part of the paper the authors point out conditions of minimal character ensuring that the set \(\operatorname {Min}A= \{a\in A\mid (a-C)\cap (A\setminus\{a\})= \emptyset ...
P. LORIDAN +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A minimal partial degree ≤𝑂^{’}
, 1973 We construct, recursively in 0’, a minimal element in the upper semilattice, excluding least element, of Turing degrees of partial functions.
Leonard P. Sasso
core +1 more source
Minimal length elements of Thompson’s groups F(p)
Geometriae Dedicata, 2009 We describe a method for determining the minimal length of elements in the generalized Thompson's groups F(p). We compute the length of an element by constructing a tree pair diagram for the element, classifying the nodes of the tree and summing associated weights from the pairs of node classifications.
Fordham, S. Blake, Cleary, Sean
openaire +3 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source