Results 81 to 90 of about 472,488 (296)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Finite elements for modeling of localized failure in reinforced concrete [PDF]

open access: yes, 2013
In this work, several beam finite element formulations are proposed for failure analysis of planar reinforced concrete beams and frames under monotonic static loading.
Jukić, Miha
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Convergence of Minimal and Approximate Minimal Elements of Sets in Partially Ordered Vector Spaces

open access: yesJournal of Mathematical Analysis and Applications, 1999
Let \(Z\) be a real normed vector space partially ordered by a closed convex pointed cone \(C\) with nonempty interior, and let \(A\) be a nonempty set in \(Z\). In the first part of the paper the authors point out conditions of minimal character ensuring that the set \(\operatorname {Min}A= \{a\in A\mid (a-C)\cap (A\setminus\{a\})= \emptyset ...
P. LORIDAN   +2 more
openaire   +3 more sources

Online preconcentration ICP-MS analysis of rare earth elements in seawater

open access: yes, 2012
The rare earth elements (REEs) with their systematically varying properties are powerful tracers of continental inputs, particle scavenging intensity and the oxidation state of seawater.
Stichel, Torben   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Explicit construction of states in orbifolds of products of N=2 superconformal ADE minimal models

open access: yesNuclear Physics B
We generalize the explicit construction of fields in orbifolds of products of N=(2,2) minimal models, developed by A. Belavin, V. Belavin and S. Parkhomenko to include minimal models with D and E-type modular invariants.
Boris Eremin, Sergej Parkhomenko
doaj   +1 more source

Minimal length elements of Thompson’s groups F(p)

open access: yesGeometriae Dedicata, 2009
We describe a method for determining the minimal length of elements in the generalized Thompson's groups F(p). We compute the length of an element by constructing a tree pair diagram for the element, classifying the nodes of the tree and summing associated weights from the pairs of node classifications.
Fordham, S. Blake, Cleary, Sean
openaire   +3 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons

open access: yesClinical and Translational Science
In 2020, BLOODPAC recommended 11 pre‐analytical minimal technical data elements for collection and submission of liquid biopsy data to public databases.
Robert L. Grossman   +21 more
doaj   +1 more source

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