Results 91 to 100 of about 3,346,804 (300)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ultima Ratio, Is the Principle at Risk?: Editors’ Introduction

Oñati Socio-Legal Series, 2013
Ultima ratio as a normative principle, or a constellation of principles, would be a hermeneutic pre-understanding or pre-interpretative concept to the effect that the definition of a certain socially relevant conduct as a crime and the consequent ...
Heike Jung, Kimmo Nuotio, Joxerramon Bengoetxea   +2 more
doaj   +2 more sources

How to make a minimal genome for synthetic minimal cell [PDF]

, 2010
As a key focus of synthetic biology, building a minimal artificial cell has given rise to many discussions. A synthetic minimal cell will provide an appropriate chassis to integrate functional synthetic parts, devices and systems with functions that ...
王晶, Zhang, Liu-yan, Chang, Su-hua, Wang, Jing   +3 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Minimal exact balancedness [PDF]

To verify whether a transferable utility game is exact, one has to check a linear inequalityfor each exact balanced collection of coalitions. This paper studies the structure andproperties of the class of exact balanced collections.
Lohmann E., Borm P., Herings P.J.J.
core   +2 more sources

Impact of the Mean Radiant Temperature (T_mrt) on Outdoor Thermal Comfort Based on Urban Renewal: A Case Study of the Panjiayuan Antique Market in Beijing, China

Buildings
Like other mega cities in China, Beijing is undergoing a large-scale urban renewal process. However, in the context of global warming and the goal of promoting human health and well-being, urban renewal should follow the principle of minimal intervention,
Chenxiao Liu, Yani Fang, Yanglu Shi, Mingli Wang, Mo Han, Xiaobing Chen   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Minimal intervention for neurofibromatosis type I manifestations: A case report. [PDF]

Int J Surg Case Rep, 2023
Saad RH, Medra AM, Saadallah OA, El Mallah MM.   +3 more
europepmc   +1 more source