Results 101 to 110 of about 3,346,804 (300)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Ultima Ratio and the Judicial Application of Law
Oñati Socio-Legal Series, 2013 The nature of Ultima Ratio as a principle, its relationship to other principles in the criminal law is the first subject of this paper. After discarding approaches that deny any role to the ultima ratio principle like the criminal law of the enemy, the ...
Joxerramon Bengoetxea
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Holomorphic curves and minimal surfaces in Kähler manifolds [PDF]
Our work is concerned with the relation between a complex differential geometric property, namely holomorphicity, and a metric one, namely to be conformal and minimal, of immersions (possibly branched) of Riemann surfaces into Kahler manifolds. A well
Arezzo, Claudio
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Crown Fragment Reattachment by the Minimal Intervention Approach for Coronal Tooth Fractures: A Case Series. [PDF]
Cureus, 2023 Jain K, Goyal L, Agarwal P.
europepmc +1 more source
Minimal Manipulability: Anonymity and Unanimity [PDF]
This paper is concerned with the minimal number of profiles at which a unanimous and anonymous social choice function is manipulable. The lower bound is derived when there are three alternatives to choose from.
Maus,Stefan, Storcken,Ton, Peters,Hans
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Causes of the Evidence-practice Gap and Its Association with the Effects of Minimal Intervention Dentistry Education to Clinicians. [PDF]
Oper Dent, 2023 Yokoyama Y +5 more
europepmc +1 more source