Results 71 to 80 of about 664,402 (295)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Percutaneous Knotless Technique for Acute Achilles Tendon Ruptures

Arthroscopy Techniques, 2018
Achilles tendon ruptures are a common tendon injury, usually occurring in middle-aged men during recreational sporting activities. Both nonoperative and operative management are employed to treat these injuries. Several operative treatments are described
Daniel J. Liechti, M.D., Gilbert Moatshe, M.D., Jonathon D. Backus, M.D., Daniel Cole Marchetti, B.A., Thomas O. Clanton, M.D.   +4 more
doaj   +1 more source

The Complexity of Repairing, Adjusting, and Aggregating of Extensions in Abstract Argumentation

, 2013
We study the computational complexity of problems that arise in abstract argumentation in the context of dynamic argumentation, minimal change, and aggregation.
D. Seese, E.J. Kim, J. Flum, K. Pietrzak, M.R. Garey, P.E. Dunne, P.E. Dunne, P.E. Dunne, P.M. Dung, R. Niedermeier, R.G. Downey, S. Coste-Marquis, S. Kreutzer, T.J.M. Bench-Capon, W. Dvorák, W. Dvorák, W. Dvořák, Y. Dimopoulos   +17 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

All-Arthroscopic Intratendinous Dermal Patch Integration for Large-Sized Rotator Cuff Tear

Arthroscopy Techniques
Patch augmentation of rotator cuff repair can create a healed tendon-bone interface, rather than the formation of a fibrovascular scar tissue, seen even after maximizing biomechanical strength of repair with a double-row construct.
Sreejith Thampy J., M.S. Ortho, Yon-Sik Yoo, M.D., Ph.D., Ayyappan V. Nair, D.N.B., M.N.A.M.S.   +2 more
doaj   +1 more source

Answer Sets for Consistent Query Answering in Inconsistent Databases

, 2002
A relational database is inconsistent if it does not satisfy a given set of integrity constraints. Nevertheless, it is likely that most of the data in it is consistent with the constraints. In this paper we apply logic programming based on answer sets to
Arenas, Marcelo, Bertossi, Leopoldo, Chomicki, Jan   +2 more
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Robotic repair of large Morgagni hernia in an adolescent girl

Journal of Pediatric Surgery Case Reports, 2019
Introduction: Successful robotic repair of Morgagni hernias has been reported a few times, but in these cases the hernia content was rather minimal or unspecified.
Ward Janssens, Martijn Schoneveld, Mathias Allaeys, Antoine De Backer   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Biocellulose for Incisional Hernia Repair—An Experimental Pilot Study

Nanomaterials, 2019
Ventral or incisional hernia are a common disease pattern in general surgery. Most commonly, a mesh repair is used for reconstruction, whereby the mesh itself might cause complications, like infections or adhesions.
Falk Rauchfuß, Julian Helble, Johanna Bruns, Olaf Dirsch, Uta Dahmen, Michael Ardelt, Utz Settmacher, Hubert Scheuerlein   +7 more
doaj   +1 more source