Results 241 to 250 of about 656,371 (370)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Practical application of minimal residual disease assessment in childhood acute lymphoblastic leukaemia [PDF]

, 2001
Nick Goulden, A Oakhill, Colin G. Steward   +2 more
openalex   +1 more source

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

FEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei, Amir Barzegar Behrooz, Marco Cordani, Mahmoud Aghaei, Negar Azarpira, Daniel J. Klionsky, Saeid Ghavami   +6 more
wiley   +1 more source

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Cellular residual disease (CRD) in early breast cancer –Expanding the concept of minimal residual disease monitoring?

The Journal of Liquid Biopsy
Despite a significant evolution in treatment strategies for early breast cancer (EBC) patients, up to 30% of them experience recurrence due to occult micrometastasis.
Mara S. Serafini, Elisabetta Molteni, Eleonora Nicolò, Lorenzo Gerratana, Carolina Reduzzi, Massimo Cristofanilli   +5 more
doaj  

Outcome prediction by immunophenotypic minimal residual disease detection in adult T‐cell acute lymphoblastic leukaemia [PDF]

, 2002
Mauro Krampera, Antonella Vitale, C. Vincenzi, Omar Perbellini, Anna Guarini, Luciana Annino, Giuseppe Todeschini, Andrea Camera, Francesco Fabbiano, Giuseppe Fioritoni, Francesco Nobile, Richard Szydlo, Franco Mandelli, Robin Foà, Giovanni Pizzolo   +14 more
openalex   +1 more source

Minimal Residual Disease [PDF]

, 2018
openaire   +3 more sources

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Quantification of minimal residual disease in patients with e1a2 BCR-ABL-positive acute lymphoblastic leukemia using a real-time RT-PCR assay [PDF]

, 2002
Hiromitsu Yokota, NH Tsuno, Yoshinori Tanaka, Takafumi Fukui, Kiyoshi Kitamura, Hisamaru Hirai, Kazuoki Osumi, Naoko Itou, Hiroaki Satoh, M Okabe, Ken‐ichi Nakahara   +10 more
openalex   +1 more source

Minimal residual disease in pediatric ALL

Oncotarget, 2017
Ching-Hon Pui, Dario Campana
openaire   +3 more sources